Exploring novel pharmacological trends: Natural compounds in dry eye disease management
Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity and quality of life and is influenced by age, gender, and environment...
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Sciendo
2024-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0028 |
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| author | Rák Tibor Csutak Adrienne |
| author_facet | Rák Tibor Csutak Adrienne |
| author_sort | Rák Tibor |
| collection | DOAJ |
| description | Dry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity and quality of life and is influenced by age, gender, and environmental factors. The first line of treatment consists of dynamically developing artificial tears, gels, and eyelid sprays, which can be supplemented with natural ingredients for enhanced efficacy. Other therapeutic steps include auto-logous serum tears, anti-inflammatory and immunosuppressive eyedrops, or oral tablets. Management also targets Meibomian gland dysfunction and the ocular surface micro-biome. This article explores various therapeutic approaches, including natural compounds and complementary strategies. Natural compounds, such as vitamins, and herbal substances (e.g., trehalose), offer promising benefits in enhancing tear film stability and ocular surface protection. Apitherapeutic products like manuka honey and propolis exhibit antibacterial and anti-inflammatory properties. Additionally, human tissue-derived solutions, such as auto-logous serum tears and amniotic membrane extracts, hold the potential for ocular surface regeneration. Other strategies, including polyherbal eye drops, liposomal eyelid sprays, and microbiome-supporting solutions offer alternative therapeutic avenues. Moreover, patient education, lifestyle modifications, and interdisciplinary collaboration play crucial roles in DED management, emphasizing the importance of holistic care approaches. |
| format | Article |
| id | doaj-art-f02adac066054eacbc45c899eb3429d6 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-f02adac066054eacbc45c899eb3429d62025-02-03T00:09:52ZengSciendoActa Pharmaceutica1846-95582024-09-0174338340410.2478/acph-2024-0028Exploring novel pharmacological trends: Natural compounds in dry eye disease managementRák Tibor0Csutak Adrienne1Department of Pharmacognosy, Faculty of Pharmacy University of Pécs, Pécs, HungaryDepartment of Ophthalmology, Medical School – Clinical Centre, University of Pécs, Pécs, HungaryDry eye disease (DED) is an ocular condition characterized by altered tear film homeostasis, resulting in symptoms like tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. It affects visual acuity and quality of life and is influenced by age, gender, and environmental factors. The first line of treatment consists of dynamically developing artificial tears, gels, and eyelid sprays, which can be supplemented with natural ingredients for enhanced efficacy. Other therapeutic steps include auto-logous serum tears, anti-inflammatory and immunosuppressive eyedrops, or oral tablets. Management also targets Meibomian gland dysfunction and the ocular surface micro-biome. This article explores various therapeutic approaches, including natural compounds and complementary strategies. Natural compounds, such as vitamins, and herbal substances (e.g., trehalose), offer promising benefits in enhancing tear film stability and ocular surface protection. Apitherapeutic products like manuka honey and propolis exhibit antibacterial and anti-inflammatory properties. Additionally, human tissue-derived solutions, such as auto-logous serum tears and amniotic membrane extracts, hold the potential for ocular surface regeneration. Other strategies, including polyherbal eye drops, liposomal eyelid sprays, and microbiome-supporting solutions offer alternative therapeutic avenues. Moreover, patient education, lifestyle modifications, and interdisciplinary collaboration play crucial roles in DED management, emphasizing the importance of holistic care approaches.https://doi.org/10.2478/acph-2024-0028dry eye diseaseartificial tearsvitaminsherbal eyedropapitherapyautologous human serum |
| spellingShingle | Rák Tibor Csutak Adrienne Exploring novel pharmacological trends: Natural compounds in dry eye disease management Acta Pharmaceutica dry eye disease artificial tears vitamins herbal eyedrop apitherapy autologous human serum |
| title | Exploring novel pharmacological trends: Natural compounds in dry eye disease management |
| title_full | Exploring novel pharmacological trends: Natural compounds in dry eye disease management |
| title_fullStr | Exploring novel pharmacological trends: Natural compounds in dry eye disease management |
| title_full_unstemmed | Exploring novel pharmacological trends: Natural compounds in dry eye disease management |
| title_short | Exploring novel pharmacological trends: Natural compounds in dry eye disease management |
| title_sort | exploring novel pharmacological trends natural compounds in dry eye disease management |
| topic | dry eye disease artificial tears vitamins herbal eyedrop apitherapy autologous human serum |
| url | https://doi.org/10.2478/acph-2024-0028 |
| work_keys_str_mv | AT raktibor exploringnovelpharmacologicaltrendsnaturalcompoundsindryeyediseasemanagement AT csutakadrienne exploringnovelpharmacologicaltrendsnaturalcompoundsindryeyediseasemanagement |