Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit
Purpose. In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. We sought to identify clinical characteristics and survival outcomes among HIV patients...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/2610873 |
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| author | Arthur Kwizera Mary Nabukenya Agaba Peter Lameck Semogerere Emmanuel Ayebale Catherine Katabira Samuel Kizito Cecilia Nantume Ian Clarke Jane Nakibuuka |
| author_facet | Arthur Kwizera Mary Nabukenya Agaba Peter Lameck Semogerere Emmanuel Ayebale Catherine Katabira Samuel Kizito Cecilia Nantume Ian Clarke Jane Nakibuuka |
| author_sort | Arthur Kwizera |
| collection | DOAJ |
| description | Purpose. In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. We sought to identify clinical characteristics and survival outcomes among HIV patients in a low-income country ICU. Materials and Methods. A retrospective cohort study of HIV infected patients admitted to a university teaching hospital ICU in Uganda. Medical records were reviewed. Primary outcome was survival to hospital discharge. Statistical significance was predetermined in reference to P<0.05. Results. There were 101 HIV patients. Average length of ICU stay was 4 days and ICU mortality was 57%. Mortality in non-HIV patients was 28%. Commonest admission diagnoses were Acute Respiratory Distress Syndrome (ARDS) (58.4%), multiorgan failure (20.8%), and sepsis (20.8%). The mean Acute Physiologic and Chronic Health Evaluation (APACHE II) score was 24. At multivariate analysis, APACHE II (OR 1.24 (95% CI: 1.1–1.4, P=0.01)), mechanical ventilation (OR 1.14 (95% CI: 0.09–0.76, P=0.01)), and ARDS (OR 4.5 (95% CI: 1.07–16.7, P=0.04)) had a statistically significant association with mortality. Conclusion. ICU mortality of HIV patients is higher than in higher income settings and the non-HIV population. ARDS, APACHE II, and need for mechanical ventilation are significantly associated with mortality. |
| format | Article |
| id | doaj-art-f01660723af14014972a637c351ad45e |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-f01660723af14014972a637c351ad45e2025-02-03T05:47:51ZengWileyCritical Care Research and Practice2090-13052090-13132016-01-01201610.1155/2016/26108732610873Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care UnitArthur Kwizera0Mary Nabukenya1Agaba Peter2Lameck Semogerere3Emmanuel Ayebale4Catherine Katabira5Samuel Kizito6Cecilia Nantume7Ian Clarke8Jane Nakibuuka9Department of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Clinical Epidemiology and Biostatistics, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaInternational Health Sciences University and International Hospital Kampala, Kampala, UgandaInternational Health Sciences University and International Hospital Kampala, Kampala, UgandaDepartment of Medicine, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaPurpose. In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. We sought to identify clinical characteristics and survival outcomes among HIV patients in a low-income country ICU. Materials and Methods. A retrospective cohort study of HIV infected patients admitted to a university teaching hospital ICU in Uganda. Medical records were reviewed. Primary outcome was survival to hospital discharge. Statistical significance was predetermined in reference to P<0.05. Results. There were 101 HIV patients. Average length of ICU stay was 4 days and ICU mortality was 57%. Mortality in non-HIV patients was 28%. Commonest admission diagnoses were Acute Respiratory Distress Syndrome (ARDS) (58.4%), multiorgan failure (20.8%), and sepsis (20.8%). The mean Acute Physiologic and Chronic Health Evaluation (APACHE II) score was 24. At multivariate analysis, APACHE II (OR 1.24 (95% CI: 1.1–1.4, P=0.01)), mechanical ventilation (OR 1.14 (95% CI: 0.09–0.76, P=0.01)), and ARDS (OR 4.5 (95% CI: 1.07–16.7, P=0.04)) had a statistically significant association with mortality. Conclusion. ICU mortality of HIV patients is higher than in higher income settings and the non-HIV population. ARDS, APACHE II, and need for mechanical ventilation are significantly associated with mortality.http://dx.doi.org/10.1155/2016/2610873 |
| spellingShingle | Arthur Kwizera Mary Nabukenya Agaba Peter Lameck Semogerere Emmanuel Ayebale Catherine Katabira Samuel Kizito Cecilia Nantume Ian Clarke Jane Nakibuuka Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit Critical Care Research and Practice |
| title | Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit |
| title_full | Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit |
| title_fullStr | Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit |
| title_full_unstemmed | Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit |
| title_short | Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit |
| title_sort | clinical characteristics and short term outcomes of hiv patients admitted to an african intensive care unit |
| url | http://dx.doi.org/10.1155/2016/2610873 |
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