Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study
Abstract Background and aim Remimazolam has proved to be a very promising sedative drug in randomized clinical trials for usage in a wide spectrum of patients, including critically ill ones. The purpose of our study was to verify efficacy and safety of remimazolam for procedural sedation during diag...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03636-1 |
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| author | Conigliaro Rita Pigò Flavia Caiazzo Anna Grande Giuseppe Russo Salvatore Cocca Silvia Lupo Marinella Marocchi Margherita Marsico Maria Sculli Simone Bertani Helga |
| author_facet | Conigliaro Rita Pigò Flavia Caiazzo Anna Grande Giuseppe Russo Salvatore Cocca Silvia Lupo Marinella Marocchi Margherita Marsico Maria Sculli Simone Bertani Helga |
| author_sort | Conigliaro Rita |
| collection | DOAJ |
| description | Abstract Background and aim Remimazolam has proved to be a very promising sedative drug in randomized clinical trials for usage in a wide spectrum of patients, including critically ill ones. The purpose of our study was to verify efficacy and safety of remimazolam for procedural sedation during diagnostic and first level operative endoscopy in a real-world setting. Methods This single centre prospective study evaluated sedation regimen with remimazolam for EGDS and fentanyl and remimazolam for colonoscopy in consecutive ASA 1–3 patients. Results Seventy-one patients underwent 73 procedures (25 EGDS, 48 colonoscopies) with a total amount of 13.2 ± 8.7 mg and 10.2 ± 6.2 mg of remimazolam administered respectively. In 6 EGDS, rescue sedation with propofol was needed. Transient hypotension was frequent (37%) and no cases of hypoxia occurred. One case of suspected allergy (erythema of the trunk) without anaphylaxis was reported. Conclusions Procedural sedation can be applied with remimazolam without the use of propofol, obtaining effective sedation in colonoscopies while in EGDS remimazolam alone guarantees the result in a percentage of around 70–75% of cases. |
| format | Article |
| id | doaj-art-f0101ea2a54a4c968d326bb985593ebe |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-f0101ea2a54a4c968d326bb985593ebe2025-02-02T12:27:12ZengBMCBMC Gastroenterology1471-230X2025-01-012511810.1186/s12876-025-03636-1Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational studyConigliaro Rita0Pigò Flavia1Caiazzo Anna2Grande Giuseppe3Russo Salvatore4Cocca Silvia5Lupo Marinella6Marocchi Margherita7Marsico Maria8Sculli Simone9Bertani Helga10Gastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology Unit, Università degli Studi di Napoli Federico IIGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaAnaesthesiology Department, Azienda Ospedaliero Universitaria ModenaGastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria ModenaAbstract Background and aim Remimazolam has proved to be a very promising sedative drug in randomized clinical trials for usage in a wide spectrum of patients, including critically ill ones. The purpose of our study was to verify efficacy and safety of remimazolam for procedural sedation during diagnostic and first level operative endoscopy in a real-world setting. Methods This single centre prospective study evaluated sedation regimen with remimazolam for EGDS and fentanyl and remimazolam for colonoscopy in consecutive ASA 1–3 patients. Results Seventy-one patients underwent 73 procedures (25 EGDS, 48 colonoscopies) with a total amount of 13.2 ± 8.7 mg and 10.2 ± 6.2 mg of remimazolam administered respectively. In 6 EGDS, rescue sedation with propofol was needed. Transient hypotension was frequent (37%) and no cases of hypoxia occurred. One case of suspected allergy (erythema of the trunk) without anaphylaxis was reported. Conclusions Procedural sedation can be applied with remimazolam without the use of propofol, obtaining effective sedation in colonoscopies while in EGDS remimazolam alone guarantees the result in a percentage of around 70–75% of cases.https://doi.org/10.1186/s12876-025-03636-1SedationGastrointestinal endoscopySafety |
| spellingShingle | Conigliaro Rita Pigò Flavia Caiazzo Anna Grande Giuseppe Russo Salvatore Cocca Silvia Lupo Marinella Marocchi Margherita Marsico Maria Sculli Simone Bertani Helga Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study BMC Gastroenterology Sedation Gastrointestinal endoscopy Safety |
| title | Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study |
| title_full | Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study |
| title_fullStr | Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study |
| title_full_unstemmed | Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study |
| title_short | Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study |
| title_sort | remimazolam for procedural sedation in gastrointestinal endoscopy real life single center observational study |
| topic | Sedation Gastrointestinal endoscopy Safety |
| url | https://doi.org/10.1186/s12876-025-03636-1 |
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