A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations
Historically, <i>EGFR</i> and <i>KRAS</i> mutations were believed to be mutually exclusive. However, over the past few years, there have been emerging case reports showing the co-existence of both mutations in a single case. The majority of these co-occurring alterations were...
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2025-01-01
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| author | Abhimanyu Tushir Israh Akhtar Anjali Seth |
| author_facet | Abhimanyu Tushir Israh Akhtar Anjali Seth |
| author_sort | Abhimanyu Tushir |
| collection | DOAJ |
| description | Historically, <i>EGFR</i> and <i>KRAS</i> mutations were believed to be mutually exclusive. However, over the past few years, there have been emerging case reports showing the co-existence of both mutations in a single case. The majority of these co-occurring alterations were detected in samples collected from patients with resistance to tyrosine kinase inhibitor (TKI) treatment, indicating a potential functional role in driving resistance to therapy. These co-occurring tumor genomic alterations are not necessarily mutually exclusive, and evidence suggests that multiple clonal and sub-clonal cancer cell populations can co-exist and contribute to <i>EGFR</i> TKI resistance. We have reported such a case of concomitant <i>EGFR</i> and <i>KRAS</i> mutation in a 64-year-old female. This case highlights the importance of continuous molecular testing in managing NSCLC, especially in cases with rare mutation profiles. The emergence of new mutations during treatment can significantly impact the course of therapy and patient outcomes. In this case, the detection of both <i>EGFR</i> and <i>KRAS</i> mutations guided the selection of an appropriate targeted therapeutic strategy, including the use of Amivantamab. |
| format | Article |
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| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-f00e3ca22e19474e900343780ee4dca42025-01-24T13:27:37ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-01-014716610.3390/cimb47010066A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> MutationsAbhimanyu Tushir0Israh Akhtar1Anjali Seth2Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA 19140, USADepartment of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA 19140, USADepartment of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA 19140, USAHistorically, <i>EGFR</i> and <i>KRAS</i> mutations were believed to be mutually exclusive. However, over the past few years, there have been emerging case reports showing the co-existence of both mutations in a single case. The majority of these co-occurring alterations were detected in samples collected from patients with resistance to tyrosine kinase inhibitor (TKI) treatment, indicating a potential functional role in driving resistance to therapy. These co-occurring tumor genomic alterations are not necessarily mutually exclusive, and evidence suggests that multiple clonal and sub-clonal cancer cell populations can co-exist and contribute to <i>EGFR</i> TKI resistance. We have reported such a case of concomitant <i>EGFR</i> and <i>KRAS</i> mutation in a 64-year-old female. This case highlights the importance of continuous molecular testing in managing NSCLC, especially in cases with rare mutation profiles. The emergence of new mutations during treatment can significantly impact the course of therapy and patient outcomes. In this case, the detection of both <i>EGFR</i> and <i>KRAS</i> mutations guided the selection of an appropriate targeted therapeutic strategy, including the use of Amivantamab.https://www.mdpi.com/1467-3045/47/1/66next-generation sequencing<i>KRAS</i><i>EGFR</i>non-small cell carcinoma |
| spellingShingle | Abhimanyu Tushir Israh Akhtar Anjali Seth A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations Current Issues in Molecular Biology next-generation sequencing <i>KRAS</i> <i>EGFR</i> non-small cell carcinoma |
| title | A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations |
| title_full | A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations |
| title_fullStr | A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations |
| title_full_unstemmed | A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations |
| title_short | A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations |
| title_sort | case of non small cell lung cancer with mutually exclusive i egfr i and i kras i mutations |
| topic | next-generation sequencing <i>KRAS</i> <i>EGFR</i> non-small cell carcinoma |
| url | https://www.mdpi.com/1467-3045/47/1/66 |
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