Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence
The surgical treatment of early breast cancer has evolved from the removal of the entire breast and surrounding tissues (mastectomy) to the removal of the tumour together with a margin of healthy tissue (lumpectomy). Adjuvant radiotherapy, however, is still mainly given to the whole breast. Furtherm...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/375170 |
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| _version_ | 1832561948393209856 |
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| author | Norman R. Williams Katharine H. Pigott Mohammed R. S. Keshtgar |
| author_facet | Norman R. Williams Katharine H. Pigott Mohammed R. S. Keshtgar |
| author_sort | Norman R. Williams |
| collection | DOAJ |
| description | The surgical treatment of early breast cancer has evolved from the removal of the entire breast and surrounding tissues (mastectomy) to the removal of the tumour together with a margin of healthy tissue (lumpectomy). Adjuvant radiotherapy, however, is still mainly given to the whole breast. Furthermore, external beam radiotherapy is often given several months after initial surgery and requires the patient to attend the radiotherapy centre daily for several weeks. A single fraction of radiotherapy given during surgery directly to the tumour bed (intraoperative radiotherapy) avoids these problems. The rationale and level-1 evidence for the safety and efficacy of the technique are reviewed. |
| format | Article |
| id | doaj-art-f0014be3017b46a086034061b948ca5f |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-f0014be3017b46a086034061b948ca5f2025-02-03T01:23:56ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/375170375170Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the EvidenceNorman R. Williams0Katharine H. Pigott1Mohammed R. S. Keshtgar2Clinical Trials Group, Division of Surgery and Interventional Science, University College London (UCL) Medical School, Archway Campus, London, N19 5LW, UKRadiotherapy Department, Royal Free Hospital, London NW3 2QG, UKDepartment of Surgery, Royal Free Hospital, London NW3 2QG, UKThe surgical treatment of early breast cancer has evolved from the removal of the entire breast and surrounding tissues (mastectomy) to the removal of the tumour together with a margin of healthy tissue (lumpectomy). Adjuvant radiotherapy, however, is still mainly given to the whole breast. Furthermore, external beam radiotherapy is often given several months after initial surgery and requires the patient to attend the radiotherapy centre daily for several weeks. A single fraction of radiotherapy given during surgery directly to the tumour bed (intraoperative radiotherapy) avoids these problems. The rationale and level-1 evidence for the safety and efficacy of the technique are reviewed.http://dx.doi.org/10.4061/2011/375170 |
| spellingShingle | Norman R. Williams Katharine H. Pigott Mohammed R. S. Keshtgar Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence International Journal of Breast Cancer |
| title | Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence |
| title_full | Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence |
| title_fullStr | Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence |
| title_full_unstemmed | Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence |
| title_short | Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence |
| title_sort | intraoperative radiotherapy in the treatment of breast cancer a review of the evidence |
| url | http://dx.doi.org/10.4061/2011/375170 |
| work_keys_str_mv | AT normanrwilliams intraoperativeradiotherapyinthetreatmentofbreastcancerareviewoftheevidence AT katharinehpigott intraoperativeradiotherapyinthetreatmentofbreastcancerareviewoftheevidence AT mohammedrskeshtgar intraoperativeradiotherapyinthetreatmentofbreastcancerareviewoftheevidence |