Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective
Purpose. To identify specific risk factors and protective factors to inform tailored screening and management strategies for high-risk individuals. Methods. This case-control study included a total of 800 eyes from 400 individuals, comprising 200 pairs of eyes diagnosed with primary open-angle glau...
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Ukrainian Society of Ophthalmologists
2025-04-01
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| Series: | Journal of Ophthalmology |
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| Online Access: | https://ua.ozhurnal.com/index.php/files/article/view/243 |
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| author | R. Babovic T. Dugandzija V. Canadanovic D. Kacavenda-Babovic |
| author_facet | R. Babovic T. Dugandzija V. Canadanovic D. Kacavenda-Babovic |
| author_sort | R. Babovic |
| collection | DOAJ |
| description | Purpose. To identify specific risk factors and protective factors to inform tailored screening and management strategies for high-risk individuals.
Methods. This case-control study included a total of 800 eyes from 400 individuals, comprising 200 pairs of eyes diagnosed with primary open-angle glaucoma (POAG) and 200 glaucoma-free (the control group). Data were collected through structured questionnaires and comprehensive ophthalmologic examinations. Statistical analyses were performed to assess the association between POAG and systemic conditions such as diabetes and hypertension, as well as various sociodemographic factors.
Results. Systolic arterial hypertension was identified as a risk factor (p<0.05), while diastolic hypertension showed a protective effect (p<0.05). Contrary to expectations, diabetes mellitus was not statistically associated with an increased risk of POAG (p>0.05).
Conclusion. The results emphasize the importance of arterial hypertension in the pathogenesis of POAG. The lack of significant association with diabetes in this cohort may be due to population-specific factors, such as genetic background or lifestyle. These findings support the need for tailored screening programs targeting individuals with risk factors.
This study highlights the complex interaction of systemic diseases in the development of POAG. While arterial hypertension is confirmed risk factor, diabetes did not play a significant role in this cohort. Early detection through targeted screening of high-risk groups could improve the management and outcomes of glaucoma patients. |
| format | Article |
| id | doaj-art-effbd9e9ca0c44d1a85f1ca26f558d15 |
| institution | OA Journals |
| issn | 2412-8740 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-effbd9e9ca0c44d1a85f1ca26f558d152025-08-20T02:33:13ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402025-04-012222710.31288/oftalmolzh202522227Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan PerspectiveR. Babovic0https://orcid.org/0000-0002-2331-4251T. Dugandzija1https://orcid.org/0000-0001-6279-0413V. Canadanovic2D. Kacavenda-Babovic3https://orcid.org/0000-0003-1721-4139Ophthalmology Department, James Paget Hospital, Great Yarmouth; School of Medicine, University of East Anglia, Norwich, United KingdomFaculty of Medicine, University of Novi Sad, Serbia; Oncology Institute of Vojvodina, Sremska Kamenica, SerbiaEye Clinic UKCV, Medical Faculty, University of Novi Sad, SerbiaHistopathology Department, Norfolk and Norwich University Hospital, United Kingdom; Centre for Disease Control and Prevention, Institute of Public Health, Sombor, SerbiaPurpose. To identify specific risk factors and protective factors to inform tailored screening and management strategies for high-risk individuals. Methods. This case-control study included a total of 800 eyes from 400 individuals, comprising 200 pairs of eyes diagnosed with primary open-angle glaucoma (POAG) and 200 glaucoma-free (the control group). Data were collected through structured questionnaires and comprehensive ophthalmologic examinations. Statistical analyses were performed to assess the association between POAG and systemic conditions such as diabetes and hypertension, as well as various sociodemographic factors. Results. Systolic arterial hypertension was identified as a risk factor (p<0.05), while diastolic hypertension showed a protective effect (p<0.05). Contrary to expectations, diabetes mellitus was not statistically associated with an increased risk of POAG (p>0.05). Conclusion. The results emphasize the importance of arterial hypertension in the pathogenesis of POAG. The lack of significant association with diabetes in this cohort may be due to population-specific factors, such as genetic background or lifestyle. These findings support the need for tailored screening programs targeting individuals with risk factors. This study highlights the complex interaction of systemic diseases in the development of POAG. While arterial hypertension is confirmed risk factor, diabetes did not play a significant role in this cohort. Early detection through targeted screening of high-risk groups could improve the management and outcomes of glaucoma patients.https://ua.ozhurnal.com/index.php/files/article/view/243primary open angle glaucomarisk factorsdiabetesarterial hypertensionglaucoma screening |
| spellingShingle | R. Babovic T. Dugandzija V. Canadanovic D. Kacavenda-Babovic Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective Journal of Ophthalmology primary open angle glaucoma risk factors diabetes arterial hypertension glaucoma screening |
| title | Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective |
| title_full | Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective |
| title_fullStr | Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective |
| title_full_unstemmed | Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective |
| title_short | Arterial Hypertension and Diabetes Mellitus in the Pathogenesis of Primary Open-Angle Glaucoma: A Balkan Perspective |
| title_sort | arterial hypertension and diabetes mellitus in the pathogenesis of primary open angle glaucoma a balkan perspective |
| topic | primary open angle glaucoma risk factors diabetes arterial hypertension glaucoma screening |
| url | https://ua.ozhurnal.com/index.php/files/article/view/243 |
| work_keys_str_mv | AT rbabovic arterialhypertensionanddiabetesmellitusinthepathogenesisofprimaryopenangleglaucomaabalkanperspective AT tdugandzija arterialhypertensionanddiabetesmellitusinthepathogenesisofprimaryopenangleglaucomaabalkanperspective AT vcanadanovic arterialhypertensionanddiabetesmellitusinthepathogenesisofprimaryopenangleglaucomaabalkanperspective AT dkacavendababovic arterialhypertensionanddiabetesmellitusinthepathogenesisofprimaryopenangleglaucomaabalkanperspective |