Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults
Abstract To assess the diagnostic value of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in adult patients with Acute Pyelonephritis. A total of 132 participants divided into two groups as 66 Hospitalized patients aged ≥ 20 years suspected of having acute pyelonephritis and 66 age and sex...
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Nature Portfolio
2025-06-01
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| Online Access: | https://doi.org/10.1038/s41598-025-03646-9 |
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| author | Ayat Shaban Mousa ElNahal Ali Ibrahim Elsayed Abdelhalim Sally Hassan Essawy Ahmed behiry Mo’men Saadoun Nahla Nosair Hebatallah Abdelmaksoud Abdelmonsef Hossam Nabeeh Tarek Abdelbaky Diaa-Eldin Taha |
| author_facet | Ayat Shaban Mousa ElNahal Ali Ibrahim Elsayed Abdelhalim Sally Hassan Essawy Ahmed behiry Mo’men Saadoun Nahla Nosair Hebatallah Abdelmaksoud Abdelmonsef Hossam Nabeeh Tarek Abdelbaky Diaa-Eldin Taha |
| author_sort | Ayat Shaban Mousa ElNahal |
| collection | DOAJ |
| description | Abstract To assess the diagnostic value of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in adult patients with Acute Pyelonephritis. A total of 132 participants divided into two groups as 66 Hospitalized patients aged ≥ 20 years suspected of having acute pyelonephritis and 66 age and sex matched participants don’t have pyelonephritis. Acute Pyelonephritis was diagnosed in patients with fever, chills or the costovertebral angle tenderness, and bacteriuria higher than 105 CFU/mL without any other focus of infection. No statistically significant differences were observed between the pyelonephritis and non-pyelonephritis groups regarding demographic data or comorbidities. However, the pyelonephritis group exhibited statistically significant differences in Serum NGAL levels, abnormal urine analysis findings, total leukocyte count, and serum C-reactive protein (CRP) levels, with p-values less than 0.001. This study aims to evaluate the potential of Serum NGAL as an early diagnostic biomarker for pyelonephritis, offering a promising tool for timely and accurate diagnosis. |
| format | Article |
| id | doaj-art-eff8d9646af5460a85f5f3c1aff1d04e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-eff8d9646af5460a85f5f3c1aff1d04e2025-08-20T03:26:44ZengNature PortfolioScientific Reports2045-23222025-06-011511910.1038/s41598-025-03646-9Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adultsAyat Shaban Mousa ElNahal0Ali Ibrahim1Elsayed Abdelhalim2Sally Hassan Essawy3Ahmed behiry4Mo’men Saadoun5Nahla Nosair6Hebatallah Abdelmaksoud Abdelmonsef7Hossam Nabeeh8Tarek Abdelbaky9Diaa-Eldin Taha10Medical Microbiology Department, Faculty of Medicine, Kafrelsheikh UniversityUrology Department, Faculty of Medicine, Kafrelsheikh UniversityUrology Department, Faculty of Medicine, Kafrelsheikh UniversityMedical Microbiology Department, Faculty of Medicine, Kafrelsheikh UniversityUrology Department, Faculty of Medicine, Kafrelsheikh UniversityClinical Pathology Department, Faculty of Medicine, Kafrelsheikh UniversityClinical Pathology Department, Faculty of Medicine, Kafrelsheikh UniversityCommunity medicine Department, Faculty of Medicine, Kafrelsheikh UniversityUrology Department, Faculty of Medicine, Kafrelsheikh UniversityUrology Department, Faculty of Medicine, Kafrelsheikh UniversityUrology Department, Faculty of Medicine, Kafrelsheikh UniversityAbstract To assess the diagnostic value of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in adult patients with Acute Pyelonephritis. A total of 132 participants divided into two groups as 66 Hospitalized patients aged ≥ 20 years suspected of having acute pyelonephritis and 66 age and sex matched participants don’t have pyelonephritis. Acute Pyelonephritis was diagnosed in patients with fever, chills or the costovertebral angle tenderness, and bacteriuria higher than 105 CFU/mL without any other focus of infection. No statistically significant differences were observed between the pyelonephritis and non-pyelonephritis groups regarding demographic data or comorbidities. However, the pyelonephritis group exhibited statistically significant differences in Serum NGAL levels, abnormal urine analysis findings, total leukocyte count, and serum C-reactive protein (CRP) levels, with p-values less than 0.001. This study aims to evaluate the potential of Serum NGAL as an early diagnostic biomarker for pyelonephritis, offering a promising tool for timely and accurate diagnosis.https://doi.org/10.1038/s41598-025-03646-9PyelonephritisNeutrophil gelatinase-associated LipocalinBiomarkerUrinary tract infection |
| spellingShingle | Ayat Shaban Mousa ElNahal Ali Ibrahim Elsayed Abdelhalim Sally Hassan Essawy Ahmed behiry Mo’men Saadoun Nahla Nosair Hebatallah Abdelmaksoud Abdelmonsef Hossam Nabeeh Tarek Abdelbaky Diaa-Eldin Taha Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults Scientific Reports Pyelonephritis Neutrophil gelatinase-associated Lipocalin Biomarker Urinary tract infection |
| title | Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults |
| title_full | Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults |
| title_fullStr | Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults |
| title_full_unstemmed | Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults |
| title_short | Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults |
| title_sort | serum neutrophil gelatinase associated lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults |
| topic | Pyelonephritis Neutrophil gelatinase-associated Lipocalin Biomarker Urinary tract infection |
| url | https://doi.org/10.1038/s41598-025-03646-9 |
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