Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice
Stachyose is a prebiotic that traditionally extracted from plants, such as vegetable. It has been demonstrated to alleviate intestinal inflammation by regulating gut microbiota, but the mechanism has been unclear. This research aims to detect the potential mechanism of stachyose in alleviating the s...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000939 |
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| author | Chen Wang Junying Bai Botao Wang Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Huayi Suo Wei Chen Qixiao Zhai |
| author_facet | Chen Wang Junying Bai Botao Wang Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Huayi Suo Wei Chen Qixiao Zhai |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | Stachyose is a prebiotic that traditionally extracted from plants, such as vegetable. It has been demonstrated to alleviate intestinal inflammation by regulating gut microbiota, but the mechanism has been unclear. This research aims to detect the potential mechanism of stachyose in alleviating the severity of ulcerative colitis (UC). The results indicated that the administration of stachyose could recover the body weight, protect against the colonic tissue damage, reduce the pro-inflammatory cytokines levels, and reverse the histological abnormalities in UC mice. Oral stachyose could restore DSS-induced disturbance in intestinal bacteria. Besides, the metabolome result of serum samples showed that stachyose treatment significantly altered serum metabolites against inflammatory responses in colitis mice. Also, a significant correlation can be found between 23 metabolite biomarkers and 18 differential genera. Our results provided a strong foundation for the future study of the protective role of stachyose in maintaining intestinal homeostasis. |
| format | Article |
| id | doaj-art-efdf446fe38f4a97bfa9289acf832275 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-efdf446fe38f4a97bfa9289acf8322752025-02-03T05:13:52ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112622112220Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in miceChen Wang0Junying Bai1Botao Wang2Leilei Yu3Fengwei Tian4Jianxin Zhao5Hao Zhang6Huayi Suo7Wei Chen8Qixiao Zhai9College of Food Science, Southwest University, Chongqing 400715, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Bloomage Biotechnology Co., Ltd., Jinan 250000, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, ChinaCollege of Food Science, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Corresponding author at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.Stachyose is a prebiotic that traditionally extracted from plants, such as vegetable. It has been demonstrated to alleviate intestinal inflammation by regulating gut microbiota, but the mechanism has been unclear. This research aims to detect the potential mechanism of stachyose in alleviating the severity of ulcerative colitis (UC). The results indicated that the administration of stachyose could recover the body weight, protect against the colonic tissue damage, reduce the pro-inflammatory cytokines levels, and reverse the histological abnormalities in UC mice. Oral stachyose could restore DSS-induced disturbance in intestinal bacteria. Besides, the metabolome result of serum samples showed that stachyose treatment significantly altered serum metabolites against inflammatory responses in colitis mice. Also, a significant correlation can be found between 23 metabolite biomarkers and 18 differential genera. Our results provided a strong foundation for the future study of the protective role of stachyose in maintaining intestinal homeostasis.http://www.sciencedirect.com/science/article/pii/S2213453023000939StachyosePrebioticColitisMetabonomicsGut microbiota |
| spellingShingle | Chen Wang Junying Bai Botao Wang Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Huayi Suo Wei Chen Qixiao Zhai Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice Food Science and Human Wellness Stachyose Prebiotic Colitis Metabonomics Gut microbiota |
| title | Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice |
| title_full | Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice |
| title_fullStr | Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice |
| title_full_unstemmed | Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice |
| title_short | Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice |
| title_sort | stachyose modulates gut microbiota and alleviates dss induced ulcerative colitis in mice |
| topic | Stachyose Prebiotic Colitis Metabonomics Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000939 |
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