Acute Eosinophilic Ascites in a Middle-Aged Man

Eosinophilic gastroenteritis is a rare condition characterized by recurrent eosinophilic infiltration of portions of the GI tract and presenting with nonspecific GI symptoms in association with peripheral eosinophilia. Its etiology and pathogenesis remain unclear and its symptoms overlap with many G...

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Main Authors: Fadi Bleibel, Keith Fragoza, Garrey T. Faller
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2012/896523
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author Fadi Bleibel
Keith Fragoza
Garrey T. Faller
author_facet Fadi Bleibel
Keith Fragoza
Garrey T. Faller
author_sort Fadi Bleibel
collection DOAJ
description Eosinophilic gastroenteritis is a rare condition characterized by recurrent eosinophilic infiltration of portions of the GI tract and presenting with nonspecific GI symptoms in association with peripheral eosinophilia. Its etiology and pathogenesis remain unclear and its symptoms overlap with many GI and systemic diseases. Thus, both gastroenterologists and general internists need to be aware of this rare condition. We present a case of a 55-year-old male with diffuse abdominal pain and distention for two weeks. His physical examination was significant for moderate ascites. Initial work-up demonstrated severe peripheral blood eosinophilia, normal liver function tests, thickening of the stomach and small bowel wall, and elevated serum IgE. Upper endoscopy and extensive testing for malignancy and parasitic infections failed to establish a diagnosis. Ascitic fluid analysis showed significant eosinophilia. Further, a full-thickness jejunal showed marked eosinophilic infiltration of the serosa and muscularis propria. Subsequent treatment with oral prednisone resulted in normalization of laboratory and radiologic abnormalities in a few week period.
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spelling doaj-art-efdb351220f345cfb98cf2bd7a6596332025-02-03T06:07:21ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362012-01-01201210.1155/2012/896523896523Acute Eosinophilic Ascites in a Middle-Aged ManFadi Bleibel0Keith Fragoza1Garrey T. Faller2Department of Internal Medicine, Steward Carney Hospital, Tufts University, Boston, MA 02124, USADepartment of Internal Medicine, Steward Carney Hospital, Tufts University, Boston, MA 02124, USADepartment of Pathology, Steward Carney Hospital, Tufts University, Boston, MA 02124, USAEosinophilic gastroenteritis is a rare condition characterized by recurrent eosinophilic infiltration of portions of the GI tract and presenting with nonspecific GI symptoms in association with peripheral eosinophilia. Its etiology and pathogenesis remain unclear and its symptoms overlap with many GI and systemic diseases. Thus, both gastroenterologists and general internists need to be aware of this rare condition. We present a case of a 55-year-old male with diffuse abdominal pain and distention for two weeks. His physical examination was significant for moderate ascites. Initial work-up demonstrated severe peripheral blood eosinophilia, normal liver function tests, thickening of the stomach and small bowel wall, and elevated serum IgE. Upper endoscopy and extensive testing for malignancy and parasitic infections failed to establish a diagnosis. Ascitic fluid analysis showed significant eosinophilia. Further, a full-thickness jejunal showed marked eosinophilic infiltration of the serosa and muscularis propria. Subsequent treatment with oral prednisone resulted in normalization of laboratory and radiologic abnormalities in a few week period.http://dx.doi.org/10.1155/2012/896523
spellingShingle Fadi Bleibel
Keith Fragoza
Garrey T. Faller
Acute Eosinophilic Ascites in a Middle-Aged Man
Case Reports in Gastrointestinal Medicine
title Acute Eosinophilic Ascites in a Middle-Aged Man
title_full Acute Eosinophilic Ascites in a Middle-Aged Man
title_fullStr Acute Eosinophilic Ascites in a Middle-Aged Man
title_full_unstemmed Acute Eosinophilic Ascites in a Middle-Aged Man
title_short Acute Eosinophilic Ascites in a Middle-Aged Man
title_sort acute eosinophilic ascites in a middle aged man
url http://dx.doi.org/10.1155/2012/896523
work_keys_str_mv AT fadibleibel acuteeosinophilicascitesinamiddleagedman
AT keithfragoza acuteeosinophilicascitesinamiddleagedman
AT garreytfaller acuteeosinophilicascitesinamiddleagedman