Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration?
Huntington's disease (HD) is a progressive neurodegenerative disorder for which, until now, only symptomatic treatment has been available. Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. The...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Neurology International |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2035-8377/17/1/13 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587822497792000 |
|---|---|
| author | Clancy Cerejo Nicolas De Cleene Elias Mandler Katarina Schwarzová Samuel Labrecque Philipp Mahlknecht Florian Krismer Atbin Djamshidian Klaus Seppi Beatrice Heim |
| author_facet | Clancy Cerejo Nicolas De Cleene Elias Mandler Katarina Schwarzová Samuel Labrecque Philipp Mahlknecht Florian Krismer Atbin Djamshidian Klaus Seppi Beatrice Heim |
| author_sort | Clancy Cerejo |
| collection | DOAJ |
| description | Huntington's disease (HD) is a progressive neurodegenerative disorder for which, until now, only symptomatic treatment has been available. Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. These studies are in constant need of reliable biomarkers for neurodegeneration in HD. In recent years, retinal biomarkers have attracted significant attention in neurodegenerative disorders. Likewise, optical coherence tomography (OCT) is being evaluated as a potential biomarker in HD. In this article, we review the existing literature on OCT as a biomarker for neurodegeneration in HD. |
| format | Article |
| id | doaj-art-efcce4d082c34dc9bbc066ca0e300b4c |
| institution | Kabale University |
| issn | 2035-8377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-efcce4d082c34dc9bbc066ca0e300b4c2025-01-24T13:44:25ZengMDPI AGNeurology International2035-83772025-01-011711310.3390/neurolint17010013Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration?Clancy Cerejo0Nicolas De Cleene1Elias Mandler2Katarina Schwarzová3Samuel Labrecque4Philipp Mahlknecht5Florian Krismer6Atbin Djamshidian7Klaus Seppi8Beatrice Heim9Department of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck 6020, AustriaHuntington's disease (HD) is a progressive neurodegenerative disorder for which, until now, only symptomatic treatment has been available. Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. These studies are in constant need of reliable biomarkers for neurodegeneration in HD. In recent years, retinal biomarkers have attracted significant attention in neurodegenerative disorders. Likewise, optical coherence tomography (OCT) is being evaluated as a potential biomarker in HD. In this article, we review the existing literature on OCT as a biomarker for neurodegeneration in HD.https://www.mdpi.com/2035-8377/17/1/13Huntington's diseaseoptical coherence tomographyneurodegeneration |
| spellingShingle | Clancy Cerejo Nicolas De Cleene Elias Mandler Katarina Schwarzová Samuel Labrecque Philipp Mahlknecht Florian Krismer Atbin Djamshidian Klaus Seppi Beatrice Heim Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? Neurology International Huntington's disease optical coherence tomography neurodegeneration |
| title | Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? |
| title_full | Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? |
| title_fullStr | Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? |
| title_full_unstemmed | Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? |
| title_short | Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? |
| title_sort | optical coherence tomography in huntington s disease a potential future biomarker for neurodegeneration |
| topic | Huntington's disease optical coherence tomography neurodegeneration |
| url | https://www.mdpi.com/2035-8377/17/1/13 |
| work_keys_str_mv | AT clancycerejo opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT nicolasdecleene opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT eliasmandler opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT katarinaschwarzova opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT samuellabrecque opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT philippmahlknecht opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT floriankrismer opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT atbindjamshidian opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT klausseppi opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration AT beatriceheim opticalcoherencetomographyinhuntingtonsdiseaseapotentialfuturebiomarkerforneurodegeneration |