Anti-CCP: History and its Usefulness
Antibodies directed to cyclic citrullinated peptides (anti-CCP) are highly specific for rheumatoid arthritis (RA) and can easily be detected in sera by using commercially available immunoassays. The second version of the anti-CCP test (anti-CCP2) demonstrated h...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/14767050500134217 |
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| author | M. Herold V. Boeser E. Russe W. Klotz |
| author_facet | M. Herold V. Boeser E. Russe W. Klotz |
| author_sort | M. Herold |
| collection | DOAJ |
| description | Antibodies directed to cyclic citrullinated peptides (anti-CCP) are highly
specific for rheumatoid arthritis (RA) and can easily be detected in sera by using
commercially available immunoassays. The second version of the anti-CCP test
(anti-CCP2) demonstrated high specificity (89-98%) and good sensitivity (41-88%)
for RA. Commercially available ELISA methods from three different companies are
on the market. All three CCP2 assays show similar results as all CCP2 assays
use the same antigen-coated plates. This study was an evaluation of a new
automated method for the determination of anti-CCP2 in a routine laboratory
setting. Five hundred and fourty three serum samples were tested for anti-CCP2
within normal routine diagnostic using a commercially available ELISA and retested
with a prelaunch version of a new and fully-automated method (EliA™). The results
were comparable. The new automated assay is easy to
use and demonstrated a diagnostic sensitivity of 80% and specificity of 97%. |
| format | Article |
| id | doaj-art-efc78ee70fdd432f90c5f1db54558d1f |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-efc78ee70fdd432f90c5f1db54558d1f2025-02-03T05:54:13ZengWileyClinical and Developmental Immunology1740-25221740-25302005-01-0112213113510.1080/14767050500134217Anti-CCP: History and its UsefulnessM. Herold0V. Boeser1E. Russe2W. Klotz3Rheumatology Unit, Clinical Department of General Internal Medicine, Innsbruck Medical University, Innsbruck A-6020, AustriaRheumatology Unit, Clinical Department of General Internal Medicine, Innsbruck Medical University, Innsbruck A-6020, AustriaRheumatology Unit, Clinical Department of General Internal Medicine, Innsbruck Medical University, Innsbruck A-6020, AustriaRheumatology Unit, Clinical Department of General Internal Medicine, Innsbruck Medical University, Innsbruck A-6020, AustriaAntibodies directed to cyclic citrullinated peptides (anti-CCP) are highly specific for rheumatoid arthritis (RA) and can easily be detected in sera by using commercially available immunoassays. The second version of the anti-CCP test (anti-CCP2) demonstrated high specificity (89-98%) and good sensitivity (41-88%) for RA. Commercially available ELISA methods from three different companies are on the market. All three CCP2 assays show similar results as all CCP2 assays use the same antigen-coated plates. This study was an evaluation of a new automated method for the determination of anti-CCP2 in a routine laboratory setting. Five hundred and fourty three serum samples were tested for anti-CCP2 within normal routine diagnostic using a commercially available ELISA and retested with a prelaunch version of a new and fully-automated method (EliA™). The results were comparable. The new automated assay is easy to use and demonstrated a diagnostic sensitivity of 80% and specificity of 97%.http://dx.doi.org/10.1080/14767050500134217 |
| spellingShingle | M. Herold V. Boeser E. Russe W. Klotz Anti-CCP: History and its Usefulness Clinical and Developmental Immunology |
| title | Anti-CCP: History and its Usefulness |
| title_full | Anti-CCP: History and its Usefulness |
| title_fullStr | Anti-CCP: History and its Usefulness |
| title_full_unstemmed | Anti-CCP: History and its Usefulness |
| title_short | Anti-CCP: History and its Usefulness |
| title_sort | anti ccp history and its usefulness |
| url | http://dx.doi.org/10.1080/14767050500134217 |
| work_keys_str_mv | AT mherold anticcphistoryanditsusefulness AT vboeser anticcphistoryanditsusefulness AT erusse anticcphistoryanditsusefulness AT wklotz anticcphistoryanditsusefulness |