Anti-CCP: History and its Usefulness
Antibodies directed to cyclic citrullinated peptides (anti-CCP) are highly specific for rheumatoid arthritis (RA) and can easily be detected in sera by using commercially available immunoassays. The second version of the anti-CCP test (anti-CCP2) demonstrated h...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/14767050500134217 |
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| Summary: | Antibodies directed to cyclic citrullinated peptides (anti-CCP) are highly
specific for rheumatoid arthritis (RA) and can easily be detected in sera by using
commercially available immunoassays. The second version of the anti-CCP test
(anti-CCP2) demonstrated high specificity (89-98%) and good sensitivity (41-88%)
for RA. Commercially available ELISA methods from three different companies are
on the market. All three CCP2 assays show similar results as all CCP2 assays
use the same antigen-coated plates. This study was an evaluation of a new
automated method for the determination of anti-CCP2 in a routine laboratory
setting. Five hundred and fourty three serum samples were tested for anti-CCP2
within normal routine diagnostic using a commercially available ELISA and retested
with a prelaunch version of a new and fully-automated method (EliA™). The results
were comparable. The new automated assay is easy to
use and demonstrated a diagnostic sensitivity of 80% and specificity of 97%. |
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| ISSN: | 1740-2522 1740-2530 |