Efficient Synthesis of Novel Triazolo[5,1-<i>b</i>]purines by Diacetoxyiodobenzene-Mediated Oxidative Cyclization of Schiff Bases
In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-<i>b</i>]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%). The advantages of this approach include mild reaction conditions and removing the need to use transition m...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Reactions |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-781X/5/4/58 |
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| Summary: | In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-<i>b</i>]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%). The advantages of this approach include mild reaction conditions and removing the need to use transition metals. Based on the results obtained, a plausible reaction pathway was proposed. The developed approach opens new possibilities for the preparation of previously inaccessible condensed purine derivatives, which are of interest for the development of biomolecules with a variety of pharmacological applications. The structures of the compounds were confirmed by the data of <sup>1</sup>H, <sup>13</sup>C NMR spectroscopy, IR spectroscopy, and an elemental analysis. |
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| ISSN: | 2624-781X |