High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana
Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used to prevent graft rejection in solid organ transplant and graft-versus-host disease in hematopoietic stem cell transplant patients. T...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2016/4028492 |
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| author | Naomi Hauser Tanmay Sahai Rocco Richards Todd Roberts |
| author_facet | Naomi Hauser Tanmay Sahai Rocco Richards Todd Roberts |
| author_sort | Naomi Hauser |
| collection | DOAJ |
| description | Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used to prevent graft rejection in solid organ transplant and graft-versus-host disease in hematopoietic stem cell transplant patients. Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cytochrome P-450 3A enzyme. Toxicity can occur from overdosing or from drug-drug interactions with the simultaneous administration of cytochrome P-450 3A inhibitors and possibly P-glycoprotein inhibitors. Tacrolimus toxicity can be severe and may include multiorgan damage. We present a case of suspected tacrolimus toxicity in a postallogeneic hematopoietic stem cell transplant patient who was concurrently using oral marijuana. This case represents an important and growing clinical scenario with the increasing legalization and use of marijuana throughout the United States. |
| format | Article |
| id | doaj-art-efc37b6517f749c19beac4341b452912 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-efc37b6517f749c19beac4341b4529122025-02-03T07:26:12ZengWileyCase Reports in Transplantation2090-69432090-69512016-01-01201610.1155/2016/40284924028492High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized MarijuanaNaomi Hauser0Tanmay Sahai1Rocco Richards2Todd Roberts3Department of Medicine, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, USADepartment of Medicine, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, USADepartment of Medicine, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, USADepartment of Medicine, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, USATacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used to prevent graft rejection in solid organ transplant and graft-versus-host disease in hematopoietic stem cell transplant patients. Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cytochrome P-450 3A enzyme. Toxicity can occur from overdosing or from drug-drug interactions with the simultaneous administration of cytochrome P-450 3A inhibitors and possibly P-glycoprotein inhibitors. Tacrolimus toxicity can be severe and may include multiorgan damage. We present a case of suspected tacrolimus toxicity in a postallogeneic hematopoietic stem cell transplant patient who was concurrently using oral marijuana. This case represents an important and growing clinical scenario with the increasing legalization and use of marijuana throughout the United States.http://dx.doi.org/10.1155/2016/4028492 |
| spellingShingle | Naomi Hauser Tanmay Sahai Rocco Richards Todd Roberts High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana Case Reports in Transplantation |
| title | High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana |
| title_full | High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana |
| title_fullStr | High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana |
| title_full_unstemmed | High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana |
| title_short | High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana |
| title_sort | high on cannabis and calcineurin inhibitors a word of warning in an era of legalized marijuana |
| url | http://dx.doi.org/10.1155/2016/4028492 |
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