Evolutionary measures show that recurrence of DCIS is distinct from progression to breast cancer

Evolutionary measures show that recurrence of DCIS is distinct from progression to breast cancer

Abstract Background Progression from pre-cancers like ductal carcinoma in situ (DCIS) to invasive disease (cancer) is driven by somatic evolution and is altered by clinical interventions. We hypothesized that genetic and/or phenotypic intra-tumor heterogeneity would predict clinical outcomes for DCI...

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Main Authors: Angelo Fortunato, Diego Mallo, Luis Cisneros, Lorraine M. King, Aziz Khan, Christina Curtis, Marc D. Ryser, Joseph Y. Lo, Allison Hall, Jeffrey R. Marks, E. Shelley Hwang, Carlo C. Maley
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Breast Cancer Research
Subjects:
Ductal carcinoma in situ
Recurrence
Progression
Intratumor heterogeneity
Evolutionary biomarkers
Tumor evolution
Online Access:https://doi.org/10.1186/s13058-025-01966-2
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