West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient
CNS involvement by CLL is a rare occurrence, usually happening in the context of a transformation to a more aggressive lymphoma in what is known as Richter’s transformation. We report a patient with active CLL who developed confusion and was found to have West Nile encephalitis that initially mimick...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/3270348 |
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| _version_ | 1832561947688566784 |
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| author | Manuel R. Espinoza-Gutarra Sherri L. Cervantez Zohra Nooruddin |
| author_facet | Manuel R. Espinoza-Gutarra Sherri L. Cervantez Zohra Nooruddin |
| author_sort | Manuel R. Espinoza-Gutarra |
| collection | DOAJ |
| description | CNS involvement by CLL is a rare occurrence, usually happening in the context of a transformation to a more aggressive lymphoma in what is known as Richter’s transformation. We report a patient with active CLL who developed confusion and was found to have West Nile encephalitis that initially mimicked CNS involvement by CLL. The patient recovered with supportive treatment and later restarted ibrutinib therapy. This case illustrates the importance of maintaining a broad differential among cancer patients with new onset confusion as well as that of questioning malignant infiltration of CNS when there is concomitant active CNS infection. |
| format | Article |
| id | doaj-art-efb4be19f5c1432a89a25e60d09e9fab |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-efb4be19f5c1432a89a25e60d09e9fab2025-02-03T01:23:55ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/32703483270348West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia PatientManuel R. Espinoza-Gutarra0Sherri L. Cervantez1Zohra Nooruddin2Department of Internal Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USADepartment of Hematology-Oncology, Mays Cancer Center, UT Health San Antonio, 7979 Wurzbach Rd., San Antonio, TX 78229, USADepartment of Hematology-Oncology, South Texas VA, 7400 Merton Minter, San Antonio, TX 78229, USACNS involvement by CLL is a rare occurrence, usually happening in the context of a transformation to a more aggressive lymphoma in what is known as Richter’s transformation. We report a patient with active CLL who developed confusion and was found to have West Nile encephalitis that initially mimicked CNS involvement by CLL. The patient recovered with supportive treatment and later restarted ibrutinib therapy. This case illustrates the importance of maintaining a broad differential among cancer patients with new onset confusion as well as that of questioning malignant infiltration of CNS when there is concomitant active CNS infection.http://dx.doi.org/10.1155/2018/3270348 |
| spellingShingle | Manuel R. Espinoza-Gutarra Sherri L. Cervantez Zohra Nooruddin West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient Case Reports in Hematology |
| title | West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient |
| title_full | West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient |
| title_fullStr | West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient |
| title_full_unstemmed | West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient |
| title_short | West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient |
| title_sort | west nile encephalitis an unusual infection in a chronic lymphocytic leukemia patient |
| url | http://dx.doi.org/10.1155/2018/3270348 |
| work_keys_str_mv | AT manuelrespinozagutarra westnileencephalitisanunusualinfectioninachroniclymphocyticleukemiapatient AT sherrilcervantez westnileencephalitisanunusualinfectioninachroniclymphocyticleukemiapatient AT zohranooruddin westnileencephalitisanunusualinfectioninachroniclymphocyticleukemiapatient |