“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)
An expeditious, efficient, and ecofriendly ultrasound-promoted synthesis of a series of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k), as useful building block candidates for natural products and drugs, is reported. The target compounds...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/125959 |
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| author | Manouchehr Mamaghani Nosrat O. Mahmoodi Farhad Shirini Abbas Azimi-Roshan Azam Monfared |
| author_facet | Manouchehr Mamaghani Nosrat O. Mahmoodi Farhad Shirini Abbas Azimi-Roshan Azam Monfared |
| author_sort | Manouchehr Mamaghani |
| collection | DOAJ |
| description | An expeditious, efficient, and ecofriendly ultrasound-promoted synthesis of a series of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k), as useful building block candidates for natural products and drugs, is reported. The target compounds were prepared by the reaction of alkyl or aryl carboxylic acid, various bisaldehydes and isocyanocyclohexane in water using one-pot isocyanide-based multicomponent approach. This efficient protocol without using any catalyst furnished the products in short reaction times (4-5 min) and excellent yields (87–96%). The antibacterial activity of the selected products was also examined. Some products showed promising activities. |
| format | Article |
| id | doaj-art-efb3ad4377864435a4a7ae20878fe940 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-efb3ad4377864435a4a7ae20878fe9402025-02-03T01:02:31ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/125959125959“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)Manouchehr Mamaghani0Nosrat O. Mahmoodi1Farhad Shirini2Abbas Azimi-Roshan3Azam Monfared4Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, IranDepartment of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, IranDepartment of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, IranDepartment of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, IranDepartment of Chemistry, University of Payamnoor of Tehran, P.O. Box 1659639884, Tehran, IranAn expeditious, efficient, and ecofriendly ultrasound-promoted synthesis of a series of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k), as useful building block candidates for natural products and drugs, is reported. The target compounds were prepared by the reaction of alkyl or aryl carboxylic acid, various bisaldehydes and isocyanocyclohexane in water using one-pot isocyanide-based multicomponent approach. This efficient protocol without using any catalyst furnished the products in short reaction times (4-5 min) and excellent yields (87–96%). The antibacterial activity of the selected products was also examined. Some products showed promising activities.http://dx.doi.org/10.1155/2013/125959 |
| spellingShingle | Manouchehr Mamaghani Nosrat O. Mahmoodi Farhad Shirini Abbas Azimi-Roshan Azam Monfared “On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) Journal of Chemistry |
| title | “On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) |
| title_full | “On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) |
| title_fullStr | “On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) |
| title_full_unstemmed | “On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) |
| title_short | “On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) |
| title_sort | on water sonochemical multicomponent synthesis of novel bioactive 1 1 aryl bis 2 cyclohexylamino 2 oxoethane 1 1 diyl di alkanoates and benzoates |
| url | http://dx.doi.org/10.1155/2013/125959 |
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