miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1
Accumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma. miR-6869-5p has been documented to be aberrantly expressed in diverse cancers. However, the precise role of miR-6869-5p in glioma remains poorly understood. This study is a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/9752372 |
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| _version_ | 1832566104680038400 |
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| author | Fakai Wang Huanjun Zhang Bing Liu Wei Liu Zengchao Zhang |
| author_facet | Fakai Wang Huanjun Zhang Bing Liu Wei Liu Zengchao Zhang |
| author_sort | Fakai Wang |
| collection | DOAJ |
| description | Accumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma. miR-6869-5p has been documented to be aberrantly expressed in diverse cancers. However, the precise role of miR-6869-5p in glioma remains poorly understood. This study is aimed at evaluating its modifying effects on glioma. Significantly decreased expression of miR-6869-5p was found in glioma tissues and cells. Negative association was documented between miR-6869-5p and PGK1 in glioma cells, and PGK1 was demonstrated to be a targeted gene of this miRNA by luciferase reporter assay. miR-6869-5p regulated glioma cell proliferation and invasion via targeting PGK1. In addition, the survival analysis had suggested that low miR-6869-5p expression predicted poor prognosis of glioma patients. This study has suggested that miR-6869-5p is a useful tumor suppressor and prognostic marker in glioma. |
| format | Article |
| id | doaj-art-efaba91b3de74cd6b5980db1331bfa57 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-efaba91b3de74cd6b5980db1331bfa572025-02-03T01:05:06ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/97523729752372miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1Fakai Wang0Huanjun Zhang1Bing Liu2Wei Liu3Zengchao Zhang4Brain Center, Sunshine Union Hospital of Shandong Province, Weifang 261000, ChinaDepartment of Anesthesiology, Weifang Maternal and Child Health Hospital, Weifang 261000, ChinaDepartment of Neurosurgery of Affiliated Hospital, Weifang Medical University, Weifang 261000, ChinaDepartment of Neurosurgery of Affiliated Hospital, Weifang Medical University, Weifang 261000, ChinaDepartment of Neurosurgery, Weifang Chinese Medicine Hospital, Weifang 261000, ChinaAccumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma. miR-6869-5p has been documented to be aberrantly expressed in diverse cancers. However, the precise role of miR-6869-5p in glioma remains poorly understood. This study is aimed at evaluating its modifying effects on glioma. Significantly decreased expression of miR-6869-5p was found in glioma tissues and cells. Negative association was documented between miR-6869-5p and PGK1 in glioma cells, and PGK1 was demonstrated to be a targeted gene of this miRNA by luciferase reporter assay. miR-6869-5p regulated glioma cell proliferation and invasion via targeting PGK1. In addition, the survival analysis had suggested that low miR-6869-5p expression predicted poor prognosis of glioma patients. This study has suggested that miR-6869-5p is a useful tumor suppressor and prognostic marker in glioma.http://dx.doi.org/10.1155/2020/9752372 |
| spellingShingle | Fakai Wang Huanjun Zhang Bing Liu Wei Liu Zengchao Zhang miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 Mediators of Inflammation |
| title | miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 |
| title_full | miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 |
| title_fullStr | miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 |
| title_full_unstemmed | miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 |
| title_short | miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 |
| title_sort | mir 6869 5p inhibits glioma cell proliferation and invasion via targeting pgk1 |
| url | http://dx.doi.org/10.1155/2020/9752372 |
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