Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review
Major depressive disorder (MDD) affects millions of individuals and causes significant suffering worldwide. It has been speculated that MDD is associated with accelerated aging-related biological and functional decline. To examine the accelerated aging hypothesis, one of the biomarkers under study i...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Nursing Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/469070 |
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| author | Patricia Anne Kinser Debra E. Lyon |
| author_facet | Patricia Anne Kinser Debra E. Lyon |
| author_sort | Patricia Anne Kinser |
| collection | DOAJ |
| description | Major depressive disorder (MDD) affects millions of individuals and causes significant suffering worldwide. It has been speculated that MDD is associated with accelerated aging-related biological and functional decline. To examine the accelerated aging hypothesis, one of the biomarkers under study is leukocyte telomeres, and specifically the measure of telomere length and telomerase activity. This review integrates findings from eleven human studies which evaluated telomere length and telomerase activity, in order to synthesize the state of the current science and to inform the development of new knowledge and enhance nursing research of depression using appropriate biobehavioral measures. Although preliminary, the findings from this integrated review suggest that there is evidence to support a conceptualization of depression as a stress-related condition in which telomeres shorten over time in relation to cumulative exposure to the chronic stress of depression. For the purposes of testing in future nursing research, visual representations of the theoretical connection between stress vulnerabilities, depression, and health outcomes and key moderators and mediators involved in this conceptualization are provided. The findings from this review and the conceptual framework provided may be a useful step towards advancing therapeutic nursing interventions for this debilitating chronic condition. |
| format | Article |
| id | doaj-art-efa2348236704cc89ab61d0c7fd48063 |
| institution | Kabale University |
| issn | 2090-1429 2090-1437 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Nursing Research and Practice |
| spelling | doaj-art-efa2348236704cc89ab61d0c7fd480632025-02-03T05:52:41ZengWileyNursing Research and Practice2090-14292090-14372013-01-01201310.1155/2013/469070469070Major Depressive Disorder and Measures of Cellular Aging: An Integrative ReviewPatricia Anne Kinser0Debra E. Lyon1Department of Family and Community Health Nursing, School of Nursing, Virginia Commonwealth University, P.O. Box 980567, Richmond, VA 23298-0567, USADepartment of Family and Community Health Nursing, School of Nursing, Virginia Commonwealth University, P.O. Box 980567, Richmond, VA 23298-0567, USAMajor depressive disorder (MDD) affects millions of individuals and causes significant suffering worldwide. It has been speculated that MDD is associated with accelerated aging-related biological and functional decline. To examine the accelerated aging hypothesis, one of the biomarkers under study is leukocyte telomeres, and specifically the measure of telomere length and telomerase activity. This review integrates findings from eleven human studies which evaluated telomere length and telomerase activity, in order to synthesize the state of the current science and to inform the development of new knowledge and enhance nursing research of depression using appropriate biobehavioral measures. Although preliminary, the findings from this integrated review suggest that there is evidence to support a conceptualization of depression as a stress-related condition in which telomeres shorten over time in relation to cumulative exposure to the chronic stress of depression. For the purposes of testing in future nursing research, visual representations of the theoretical connection between stress vulnerabilities, depression, and health outcomes and key moderators and mediators involved in this conceptualization are provided. The findings from this review and the conceptual framework provided may be a useful step towards advancing therapeutic nursing interventions for this debilitating chronic condition.http://dx.doi.org/10.1155/2013/469070 |
| spellingShingle | Patricia Anne Kinser Debra E. Lyon Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review Nursing Research and Practice |
| title | Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review |
| title_full | Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review |
| title_fullStr | Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review |
| title_full_unstemmed | Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review |
| title_short | Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review |
| title_sort | major depressive disorder and measures of cellular aging an integrative review |
| url | http://dx.doi.org/10.1155/2013/469070 |
| work_keys_str_mv | AT patriciaannekinser majordepressivedisorderandmeasuresofcellularaginganintegrativereview AT debraelyon majordepressivedisorderandmeasuresofcellularaginganintegrativereview |