Alternative Splicing in Self-Renewal of Embryonic Stem Cells
Much of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency. In alignment with our present understanding on the genetic, protein, and epigenetic factors that may direct cell fate, we pr...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/560261 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558144336691200 |
|---|---|
| author | Clara Y. Cheong Thomas Lufkin |
| author_facet | Clara Y. Cheong Thomas Lufkin |
| author_sort | Clara Y. Cheong |
| collection | DOAJ |
| description | Much of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency. In alignment with our present understanding on the genetic, protein, and epigenetic factors that may direct cell fate, we present a short overview of the often overlooked contribution of alternative splice variants to regulatory diversity. Progressing beyond the limitations of a fixed genomic sequence, alternative splicing offers an additional layer of complexity to produce protein variants that may differ in function and localization that can direct embryonic stem cells to specific differentiation pathways. In light of the number of variants that can be produced at key ES cell genes alone, it is challenging to consider how much more multifaceted transcriptional regulation truly is, and if this can be captured more fully in future works. |
| format | Article |
| id | doaj-art-ef9d304eff1642bdb0de9ef95709532f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ef9d304eff1642bdb0de9ef95709532f2025-02-03T01:33:08ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/560261560261Alternative Splicing in Self-Renewal of Embryonic Stem CellsClara Y. Cheong0Thomas Lufkin1Stem Cell & Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, 138672, SingaporeStem Cell & Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, 138672, SingaporeMuch of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency. In alignment with our present understanding on the genetic, protein, and epigenetic factors that may direct cell fate, we present a short overview of the often overlooked contribution of alternative splice variants to regulatory diversity. Progressing beyond the limitations of a fixed genomic sequence, alternative splicing offers an additional layer of complexity to produce protein variants that may differ in function and localization that can direct embryonic stem cells to specific differentiation pathways. In light of the number of variants that can be produced at key ES cell genes alone, it is challenging to consider how much more multifaceted transcriptional regulation truly is, and if this can be captured more fully in future works.http://dx.doi.org/10.4061/2011/560261 |
| spellingShingle | Clara Y. Cheong Thomas Lufkin Alternative Splicing in Self-Renewal of Embryonic Stem Cells Stem Cells International |
| title | Alternative Splicing in Self-Renewal of Embryonic Stem Cells |
| title_full | Alternative Splicing in Self-Renewal of Embryonic Stem Cells |
| title_fullStr | Alternative Splicing in Self-Renewal of Embryonic Stem Cells |
| title_full_unstemmed | Alternative Splicing in Self-Renewal of Embryonic Stem Cells |
| title_short | Alternative Splicing in Self-Renewal of Embryonic Stem Cells |
| title_sort | alternative splicing in self renewal of embryonic stem cells |
| url | http://dx.doi.org/10.4061/2011/560261 |
| work_keys_str_mv | AT claraycheong alternativesplicinginselfrenewalofembryonicstemcells AT thomaslufkin alternativesplicinginselfrenewalofembryonicstemcells |