Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer
Background. We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods. Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed. The correlati...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2022/6333282 |
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| _version_ | 1832558353490903040 |
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| author | Wencui Kong Zongyang Yu Wenwu Wang Jingrong Yang Jingfang Wang Zhongquan Zhao |
| author_facet | Wencui Kong Zongyang Yu Wenwu Wang Jingrong Yang Jingfang Wang Zhongquan Zhao |
| author_sort | Wencui Kong |
| collection | DOAJ |
| description | Background. We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods. Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed. The correlation between EGFR mutation and ALK fusions with clinicopathologic parameters was analyzed. Results. In young NSCLC patients, adenocarcinoma is the major histology (86.9%), and the misdiagnosis rate was as high as 45.7%. EGFR gene mutation was found in 13 patients (31.7%) and common mutations were with EGFR19del mutation (7 cases, 17.1%) and EGFR21L858R mutation (4 patients, 9.7%). EGFR mutation was constantly found in adenocarcinoma and male gender, and ever smokers (100%, P<0.05). Furthermore, ALK fusions were found in 7 patients (31.8%), which include EML-4-ALK fusions; there was a trend that ALK fusions were associated with adenocarcinoma and female gender. However, there was no significant difference in overall survival between patients with or without gene mutations. Conclusions. EGFR mutation and ALK fusions are related to histology, gender, and smoke exposure in young NSCLC patients, and may be effective predictive factors. |
| format | Article |
| id | doaj-art-ef945658850a4d92a8f55a1de81c5862 |
| institution | Kabale University |
| issn | 2090-2859 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-ef945658850a4d92a8f55a1de81c58622025-02-03T01:32:36ZengWileyEmergency Medicine International2090-28592022-01-01202210.1155/2022/6333282Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung CancerWencui Kong0Zongyang Yu1Wenwu Wang2Jingrong Yang3Jingfang Wang4Zhongquan Zhao5Department of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of OncologyDepartment of Thoracic SurgeryMedical School of RehabilitationDepartment of Pulmonary and Critical Care MedicineBackground. We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods. Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed. The correlation between EGFR mutation and ALK fusions with clinicopathologic parameters was analyzed. Results. In young NSCLC patients, adenocarcinoma is the major histology (86.9%), and the misdiagnosis rate was as high as 45.7%. EGFR gene mutation was found in 13 patients (31.7%) and common mutations were with EGFR19del mutation (7 cases, 17.1%) and EGFR21L858R mutation (4 patients, 9.7%). EGFR mutation was constantly found in adenocarcinoma and male gender, and ever smokers (100%, P<0.05). Furthermore, ALK fusions were found in 7 patients (31.8%), which include EML-4-ALK fusions; there was a trend that ALK fusions were associated with adenocarcinoma and female gender. However, there was no significant difference in overall survival between patients with or without gene mutations. Conclusions. EGFR mutation and ALK fusions are related to histology, gender, and smoke exposure in young NSCLC patients, and may be effective predictive factors.http://dx.doi.org/10.1155/2022/6333282 |
| spellingShingle | Wencui Kong Zongyang Yu Wenwu Wang Jingrong Yang Jingfang Wang Zhongquan Zhao Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer Emergency Medicine International |
| title | Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer |
| title_full | Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer |
| title_fullStr | Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer |
| title_full_unstemmed | Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer |
| title_short | Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer |
| title_sort | gene mutation and its association with clinicopathological features in young patients with non small cell lung cancer |
| url | http://dx.doi.org/10.1155/2022/6333282 |
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