Paradoxical control of multifocal mammary oncogenesis by radiation therapy
In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. T...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2458886 |
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| _version_ | 1832583552406913024 |
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| author | Lorenzo Galluzzi Aitziber Buqué |
| author_facet | Lorenzo Galluzzi Aitziber Buqué |
| author_sort | Lorenzo Galluzzi |
| collection | DOAJ |
| description | In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood. |
| format | Article |
| id | doaj-art-ef7ba5ae77c244b188623bf63efe8519 |
| institution | Kabale University |
| issn | 2162-402X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-ef7ba5ae77c244b188623bf63efe85192025-01-28T11:43:43ZengTaylor & Francis GroupOncoImmunology2162-402X2025-12-0114110.1080/2162402X.2025.2458886Paradoxical control of multifocal mammary oncogenesis by radiation therapyLorenzo Galluzzi0Aitziber Buqué1Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USACancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USAIn an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood.https://www.tandfonline.com/doi/10.1080/2162402X.2025.2458886CD4+CD25+FOXP3+ TREG cellsCTLA4dendritic cellsIL-1βimmunotherapyPD-1 |
| spellingShingle | Lorenzo Galluzzi Aitziber Buqué Paradoxical control of multifocal mammary oncogenesis by radiation therapy OncoImmunology CD4+CD25+FOXP3+ TREG cells CTLA4 dendritic cells IL-1β immunotherapy PD-1 |
| title | Paradoxical control of multifocal mammary oncogenesis by radiation therapy |
| title_full | Paradoxical control of multifocal mammary oncogenesis by radiation therapy |
| title_fullStr | Paradoxical control of multifocal mammary oncogenesis by radiation therapy |
| title_full_unstemmed | Paradoxical control of multifocal mammary oncogenesis by radiation therapy |
| title_short | Paradoxical control of multifocal mammary oncogenesis by radiation therapy |
| title_sort | paradoxical control of multifocal mammary oncogenesis by radiation therapy |
| topic | CD4+CD25+FOXP3+ TREG cells CTLA4 dendritic cells IL-1β immunotherapy PD-1 |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2458886 |
| work_keys_str_mv | AT lorenzogalluzzi paradoxicalcontrolofmultifocalmammaryoncogenesisbyradiationtherapy AT aitziberbuque paradoxicalcontrolofmultifocalmammaryoncogenesisbyradiationtherapy |