Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages
<b>Aim:</b> The aim of this study was to investigate that effect of Nerium oleander (NO) distillate on doxorubicin-induced oxidative damage and other side effects.<p> <b>Materials and Methods:</b> NO leaves were collected, distillated and lyophilized. In the current res...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1032 |
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| author | Burak Dik Ayşe Er Orhan Çorum |
| author_facet | Burak Dik Ayşe Er Orhan Çorum |
| author_sort | Burak Dik |
| collection | DOAJ |
| description | <b>Aim:</b> The aim of this study was to investigate that effect of Nerium
oleander (NO) distillate on doxorubicin-induced oxidative
damage and other side effects.<p>
<b>Materials and Methods:</b> NO leaves were collected, distillated
and lyophilized. In the current research, 28 rats were divided
into 4 groups; Control, Doxorubicin (3 mg/kg, every other day,
intraperitoneally), NO (1 mg/kg, SID, PO) and Doxorubicin (3
mg/kg, every other day, intraperitoneally) + NO (1 mg/kg, SID,
PO). All treatments were performed 11 days. At 24 hours after
the last administration, blood samples were taken from the
hearts under general anesthetizes, and euthanized immediately.
Also, heart, liver and kidney were taken and homogenized. Tissue
thiobarbituric acid reactive substances (TBARS) levels, serum
biochemical and hemogram values were measured by ELISA,
autoanalyzer and blood cell counter, respectively.<p>
<b>Results:</b> Heart TBARS values of the doxorubicin group were
lower (P<0.05) than Doxorubicin + NO distillate group, while
kidney TBARS values of the doxorubicin group were higher
(P<0.05) than the NO distillate group. Although doxorubicin decreased
(P<0.05) blood cell counts, hemoglobin and hematocrit
levels compared to Control group, administration of doxorubicin
+ NO distillate ameliorated only hematocrit levels. Doxorubicin
decreased (P<0.05) serum total protein and albumin levels
compared to Control group, while Doxorubicin + NO distillate
increased (P<0.05) aspartate aminotransferase and blood urea
nitrogen levels and decreased (P<0.05) total protein, albumin
and creatinine levels.<p>
<b>Conclusions:</b> It may be stated that levels of NO distillate used
in the current research do not prevent the doxorubicin caused
side effects. |
| format | Article |
| id | doaj-art-ef623b25fc7443b79adaea0e3dd2d8f8 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-ef623b25fc7443b79adaea0e3dd2d8f82025-02-03T11:25:39ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-195330263671032Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damagesBurak Dik0Ayşe Er1Orhan Çorum2Selçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeDicle Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Diyarbakır, Türkiye<b>Aim:</b> The aim of this study was to investigate that effect of Nerium oleander (NO) distillate on doxorubicin-induced oxidative damage and other side effects.<p> <b>Materials and Methods:</b> NO leaves were collected, distillated and lyophilized. In the current research, 28 rats were divided into 4 groups; Control, Doxorubicin (3 mg/kg, every other day, intraperitoneally), NO (1 mg/kg, SID, PO) and Doxorubicin (3 mg/kg, every other day, intraperitoneally) + NO (1 mg/kg, SID, PO). All treatments were performed 11 days. At 24 hours after the last administration, blood samples were taken from the hearts under general anesthetizes, and euthanized immediately. Also, heart, liver and kidney were taken and homogenized. Tissue thiobarbituric acid reactive substances (TBARS) levels, serum biochemical and hemogram values were measured by ELISA, autoanalyzer and blood cell counter, respectively.<p> <b>Results:</b> Heart TBARS values of the doxorubicin group were lower (P<0.05) than Doxorubicin + NO distillate group, while kidney TBARS values of the doxorubicin group were higher (P<0.05) than the NO distillate group. Although doxorubicin decreased (P<0.05) blood cell counts, hemoglobin and hematocrit levels compared to Control group, administration of doxorubicin + NO distillate ameliorated only hematocrit levels. Doxorubicin decreased (P<0.05) serum total protein and albumin levels compared to Control group, while Doxorubicin + NO distillate increased (P<0.05) aspartate aminotransferase and blood urea nitrogen levels and decreased (P<0.05) total protein, albumin and creatinine levels.<p> <b>Conclusions:</b> It may be stated that levels of NO distillate used in the current research do not prevent the doxorubicin caused side effects.http://eurasianjvetsci.org/pdf.php3?id=1032doxorubicinnerium oleanderside effect |
| spellingShingle | Burak Dik Ayşe Er Orhan Çorum Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages Eurasian Journal of Veterinary Sciences doxorubicin nerium oleander side effect |
| title | Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages |
| title_full | Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages |
| title_fullStr | Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages |
| title_full_unstemmed | Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages |
| title_short | Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages |
| title_sort | determination of protective effectiveness of nerium oleander distillation in doxorubicin induced organ damages |
| topic | doxorubicin nerium oleander side effect |
| url | http://eurasianjvetsci.org/pdf.php3?id=1032 |
| work_keys_str_mv | AT burakdik determinationofprotectiveeffectivenessofneriumoleanderdistillationindoxorubicininducedorgandamages AT ayseer determinationofprotectiveeffectivenessofneriumoleanderdistillationindoxorubicininducedorgandamages AT orhancorum determinationofprotectiveeffectivenessofneriumoleanderdistillationindoxorubicininducedorgandamages |