Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method
Abstract Background and Aim Previously observed associations between interpregnancy interval (IPI) and perinatal outcomes using a between‐individual method may be confounded by unmeasured maternal factors. This study aims to examine the association between IPI and adverse perinatal outcomes using wi...
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Wiley
2024-08-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.2313 |
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| author | Maria Sevoyan Marco Geraci Edward A. Frongillo Jihong Liu Nansi S. Boghossian |
| author_facet | Maria Sevoyan Marco Geraci Edward A. Frongillo Jihong Liu Nansi S. Boghossian |
| author_sort | Maria Sevoyan |
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| description | Abstract Background and Aim Previously observed associations between interpregnancy interval (IPI) and perinatal outcomes using a between‐individual method may be confounded by unmeasured maternal factors. This study aims to examine the association between IPI and adverse perinatal outcomes using within‐individual comparative analyses. Methods We studied 10,647 individuals from the National Institute of Child Health and Human Development Consecutive Pregnancies Study in Utah with ≥3 liveborn singleton pregnancies. We matched two IPIs per individual and used conditional logistic regression to examine the association between IPI and adverse perinatal outcomes, including preterm birth (PTB, <37 weeks’ gestation), small‐for‐gestational‐age (SGA, <10th percentile of sex‐specific birthweight for gestational age), low birthweight (LBW, <2,500 g), and neonatal intensive care unit (NICU) admission. Point and 95% confidence interval (CI) estimates were adjusted for factors that vary across pregnancies within individuals. Results CIs did not unequivocally support either an increase or a decrease in the odds of PTB (adjusted odds ratio [aOR]: 1.31, 95% CI: 0.87, 1.96), SGA (aOR: 0.81, 95% CI: 0.51, 1.28), LBW (aOR: 1.59, 95% CI: 0.90, 2.80), or NICU admission (aOR: 0.96, 95% CI: 0.66, 1.40) for an IPI <6 months compared to 18–23‐months IPI (reference), and neither did the CIs for the aOR of IPIs of 6–11 and 12–18 months compared to the reference. In contrast, an IPI ≥24 months was associated with increased odds of LBW (aOR: 1.66, 95% CI: 1.03, 2.66 for 24–29 months; aOR: 2.27, 95% CI: 1.21, 4.29 for 30–35 months; and aOR: 2.09, 95% CI: 1.17, 3.72 for ≥36 months). Conclusions Using a within‐individual comparative method, we did not find evidence that a short IPI compared to the recommended IPI of 18–23 months was associated with increased odds of PTB, SGA, LBW, and NICU admission. IPI ≥ 24 months was associated with increased odds of delivering an LBW infant. |
| format | Article |
| id | doaj-art-ef5a1ec7bd4d45c9ade3e06c9bba2f74 |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
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| series | Health Science Reports |
| spelling | doaj-art-ef5a1ec7bd4d45c9ade3e06c9bba2f742025-08-20T03:44:03ZengWileyHealth Science Reports2398-88352024-08-0178n/an/a10.1002/hsr2.2313Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative methodMaria Sevoyan0Marco Geraci1Edward A. Frongillo2Jihong Liu3Nansi S. Boghossian4Department of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina Columbia South Carolina USADepartment of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina Columbia South Carolina USADepartment of Health Promotion, Education, and Behavior Arnold School of Public Health, University of South Carolina Columbia South Carolina USADepartment of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina Columbia South Carolina USADepartment of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina Columbia South Carolina USAAbstract Background and Aim Previously observed associations between interpregnancy interval (IPI) and perinatal outcomes using a between‐individual method may be confounded by unmeasured maternal factors. This study aims to examine the association between IPI and adverse perinatal outcomes using within‐individual comparative analyses. Methods We studied 10,647 individuals from the National Institute of Child Health and Human Development Consecutive Pregnancies Study in Utah with ≥3 liveborn singleton pregnancies. We matched two IPIs per individual and used conditional logistic regression to examine the association between IPI and adverse perinatal outcomes, including preterm birth (PTB, <37 weeks’ gestation), small‐for‐gestational‐age (SGA, <10th percentile of sex‐specific birthweight for gestational age), low birthweight (LBW, <2,500 g), and neonatal intensive care unit (NICU) admission. Point and 95% confidence interval (CI) estimates were adjusted for factors that vary across pregnancies within individuals. Results CIs did not unequivocally support either an increase or a decrease in the odds of PTB (adjusted odds ratio [aOR]: 1.31, 95% CI: 0.87, 1.96), SGA (aOR: 0.81, 95% CI: 0.51, 1.28), LBW (aOR: 1.59, 95% CI: 0.90, 2.80), or NICU admission (aOR: 0.96, 95% CI: 0.66, 1.40) for an IPI <6 months compared to 18–23‐months IPI (reference), and neither did the CIs for the aOR of IPIs of 6–11 and 12–18 months compared to the reference. In contrast, an IPI ≥24 months was associated with increased odds of LBW (aOR: 1.66, 95% CI: 1.03, 2.66 for 24–29 months; aOR: 2.27, 95% CI: 1.21, 4.29 for 30–35 months; and aOR: 2.09, 95% CI: 1.17, 3.72 for ≥36 months). Conclusions Using a within‐individual comparative method, we did not find evidence that a short IPI compared to the recommended IPI of 18–23 months was associated with increased odds of PTB, SGA, LBW, and NICU admission. IPI ≥ 24 months was associated with increased odds of delivering an LBW infant.https://doi.org/10.1002/hsr2.2313adverse perinatal outcomesbirth spacinginterpregnancy intervalsibling comparisonwithin‐individual comparisonwithin‐woman comparison |
| spellingShingle | Maria Sevoyan Marco Geraci Edward A. Frongillo Jihong Liu Nansi S. Boghossian Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method Health Science Reports adverse perinatal outcomes birth spacing interpregnancy interval sibling comparison within‐individual comparison within‐woman comparison |
| title | Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method |
| title_full | Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method |
| title_fullStr | Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method |
| title_full_unstemmed | Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method |
| title_short | Interpregnancy interval and adverse perinatal outcomes: A within‐individual comparative method |
| title_sort | interpregnancy interval and adverse perinatal outcomes a within individual comparative method |
| topic | adverse perinatal outcomes birth spacing interpregnancy interval sibling comparison within‐individual comparison within‐woman comparison |
| url | https://doi.org/10.1002/hsr2.2313 |
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