Functions and applications of RNA interference and small regulatory RNAs
Small regulatory RNAs play a variety of crucial roles in eukaryotes, influencing gene regulation, developmental timing, antiviral defense, and genome integrity via a process termed RNA interference (RNAi). This process involves Argonaute/sm...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-11-01
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| Series: | Acta Biochimica et Biophysica Sinica |
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| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024196 |
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| author | Feng Xuezhu Guang Shouhong |
| author_facet | Feng Xuezhu Guang Shouhong |
| author_sort | Feng Xuezhu |
| collection | DOAJ |
| description | Small regulatory RNAs play a variety of crucial roles in eukaryotes, influencing gene regulation, developmental timing, antiviral defense, and genome integrity via a process termed RNA interference (RNAi). This process involves Argonaute/small RNA (AGO/sRNA) complexes that target transcripts via sequence complementarity and modulate gene expression and epigenetic modifications. RNAi is a highly conserved gene regulatory phenomenon that recognizes self- and non-self nucleic acids, thereby defending against invasive sequences. Since its discovery, RNAi has been widely applied in functional genomic studies and a range of practical applications. In this review, we focus on the current understanding of the biological roles of the RNAi pathway in transposon silencing, fertility, developmental regulation, immunity, stress responses, and acquired transgenerational inheritance. Additionally, we provide an overview of the applications of RNAi technology in biomedical research, agriculture, and therapeutics. |
| format | Article |
| id | doaj-art-ef492f8a29c64373b3b8f859bd8fb157 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-ef492f8a29c64373b3b8f859bd8fb1572025-01-24T00:56:49ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-11-015711913010.3724/abbs.202419620d259ccFunctions and applications of RNA interference and small regulatory RNAsFeng Xuezhu0Guang Shouhong1["School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China"]["Department of Obstetrics and Gynecology, the First Affiliated Hospital of USTC, The USTC RNA Institute, Ministry of Education Key Laboratory for Membraneless Organelles & Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Life Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230027, China"]Small regulatory RNAs play a variety of crucial roles in eukaryotes, influencing gene regulation, developmental timing, antiviral defense, and genome integrity via a process termed RNA interference (RNAi). This process involves Argonaute/small RNA (AGO/sRNA) complexes that target transcripts via sequence complementarity and modulate gene expression and epigenetic modifications. RNAi is a highly conserved gene regulatory phenomenon that recognizes self- and non-self nucleic acids, thereby defending against invasive sequences. Since its discovery, RNAi has been widely applied in functional genomic studies and a range of practical applications. In this review, we focus on the current understanding of the biological roles of the RNAi pathway in transposon silencing, fertility, developmental regulation, immunity, stress responses, and acquired transgenerational inheritance. Additionally, we provide an overview of the applications of RNAi technology in biomedical research, agriculture, and therapeutics.https://www.sciengine.com/doi/10.3724/abbs.2024196RNAisiRNAmicroRNApiRNA |
| spellingShingle | Feng Xuezhu Guang Shouhong Functions and applications of RNA interference and small regulatory RNAs Acta Biochimica et Biophysica Sinica RNAi siRNA microRNA piRNA |
| title | Functions and applications of RNA interference and small regulatory RNAs |
| title_full | Functions and applications of RNA interference and small regulatory RNAs |
| title_fullStr | Functions and applications of RNA interference and small regulatory RNAs |
| title_full_unstemmed | Functions and applications of RNA interference and small regulatory RNAs |
| title_short | Functions and applications of RNA interference and small regulatory RNAs |
| title_sort | functions and applications of rna interference and small regulatory rnas |
| topic | RNAi siRNA microRNA piRNA |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024196 |
| work_keys_str_mv | AT fengxuezhu functionsandapplicationsofrnainterferenceandsmallregulatoryrnas AT guangshouhong functionsandapplicationsofrnainterferenceandsmallregulatoryrnas |