Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy
We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels P<0.001, highe...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/807209 |
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| author | Pandelis Fotiou Athanasios Raptis George Apergis George Dimitriadis Ioannis Vergados Panagiotis Theodossiadis |
| author_facet | Pandelis Fotiou Athanasios Raptis George Apergis George Dimitriadis Ioannis Vergados Panagiotis Theodossiadis |
| author_sort | Pandelis Fotiou |
| collection | DOAJ |
| description | We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels P<0.001, higher prevalence of hyperhomocysteinemia P<0.001, lower serum folic acid P<0.001, and vitamin B12 (P=0.014) levels than those without diabetic retinopathy. Regression analysis revealed that homocysteine was an independent risk factor for diabetic retinopathy and there was a threshold in its serum level (13.7 μmol/L), above which the risk of diabetic retinopathy greatly increases (OR=1.66, P=0.001). Folic acid was associated with decreased odds for diabetic retinopathy (OR=0.73, P<0.001). There was a threshold in serum vitamin B12 level (248.4 pg/mL), below which serum homocysteine concentration significantly increases with decreasing serum vitamin B12 (P=0.003). Our findings suggest that hyperhomocysteinemia is an independent risk factor for the development and progression of diabetic retinopathy. Decreased serum levels of folic acid and vitamin B12, through raising serum homocysteine concentrations, may also affect the diabetic retinopathy risk. |
| format | Article |
| id | doaj-art-ef34b50aa97c4df5a90babab5013567c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ef34b50aa97c4df5a90babab5013567c2025-02-03T01:21:38ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/807209807209Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic RetinopathyPandelis Fotiou0Athanasios Raptis1George Apergis2George Dimitriadis3Ioannis Vergados4Panagiotis Theodossiadis52nd Department of Ophthalmology, “Attikon” University Hospital, Athens University Medical School, 1 Rimini Street, 12462 Athens, Greece2nd Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, “Attikon” University Hospital, Athens University Medical School, 1 Rimini Street, 12462 Athens, GreeceDepartment of Molecular Diagnosis, “Hippokration” General Hospital, 114 Vasilissis Sofias Avenue, 11527 Athens, Greece2nd Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, “Attikon” University Hospital, Athens University Medical School, 1 Rimini Street, 12462 Athens, GreeceAthens Eye Hospital, 45 Vouliagmenis Avenue, 16675 Athens, Greece2nd Department of Ophthalmology, “Attikon” University Hospital, Athens University Medical School, 1 Rimini Street, 12462 Athens, GreeceWe investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels P<0.001, higher prevalence of hyperhomocysteinemia P<0.001, lower serum folic acid P<0.001, and vitamin B12 (P=0.014) levels than those without diabetic retinopathy. Regression analysis revealed that homocysteine was an independent risk factor for diabetic retinopathy and there was a threshold in its serum level (13.7 μmol/L), above which the risk of diabetic retinopathy greatly increases (OR=1.66, P=0.001). Folic acid was associated with decreased odds for diabetic retinopathy (OR=0.73, P<0.001). There was a threshold in serum vitamin B12 level (248.4 pg/mL), below which serum homocysteine concentration significantly increases with decreasing serum vitamin B12 (P=0.003). Our findings suggest that hyperhomocysteinemia is an independent risk factor for the development and progression of diabetic retinopathy. Decreased serum levels of folic acid and vitamin B12, through raising serum homocysteine concentrations, may also affect the diabetic retinopathy risk.http://dx.doi.org/10.1155/2014/807209 |
| spellingShingle | Pandelis Fotiou Athanasios Raptis George Apergis George Dimitriadis Ioannis Vergados Panagiotis Theodossiadis Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy Journal of Diabetes Research |
| title | Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy |
| title_full | Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy |
| title_fullStr | Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy |
| title_full_unstemmed | Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy |
| title_short | Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy |
| title_sort | vitamin status as a determinant of serum homocysteine concentration in type 2 diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2014/807209 |
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