The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research
Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/167265 |
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| _version_ | 1832562846611800064 |
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| author | Daniil Simanov Imre Mellaart-Straver Irina Sormacheva Eugene Berezikov |
| author_facet | Daniil Simanov Imre Mellaart-Straver Irina Sormacheva Eugene Berezikov |
| author_sort | Daniil Simanov |
| collection | DOAJ |
| description | Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH, cell volume, and membrane potentials. Together with ion transporters and gap junction complexes, ion channels form steady-state voltage gradients across the cell membranes in nonexcitable cells. These membrane potentials are involved in regulation of such processes as migration guidance, cell proliferation, and body axis patterning during development and regeneration. While the importance of membrane potential in stem cell maintenance, proliferation, and differentiation is evident, the mechanisms of this bioelectric control of stem cell activity are still not well understood, and the role of specific ion channels in these processes remains unclear. Here we introduce the flatworm Macrostomum lignano as a versatile model organism for addressing these topics. We discuss biological and experimental properties of M. lignano, provide an overview of the recently developed experimental tools for this animal model, and demonstrate how manipulation of membrane potential influences regeneration in M. lignano. |
| format | Article |
| id | doaj-art-ef2bcd53a86f4e539d238c75c1682585 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ef2bcd53a86f4e539d238c75c16825852025-02-03T01:21:41ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/167265167265The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell ResearchDaniil Simanov0Imre Mellaart-Straver1Irina Sormacheva2Eugene Berezikov3Hubrecht Institute, KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The NetherlandsHubrecht Institute, KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The NetherlandsInstitute of Cytology and Genetics SB RAS, 630090 Novosibirsk, RussiaHubrecht Institute, KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The NetherlandsBioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH, cell volume, and membrane potentials. Together with ion transporters and gap junction complexes, ion channels form steady-state voltage gradients across the cell membranes in nonexcitable cells. These membrane potentials are involved in regulation of such processes as migration guidance, cell proliferation, and body axis patterning during development and regeneration. While the importance of membrane potential in stem cell maintenance, proliferation, and differentiation is evident, the mechanisms of this bioelectric control of stem cell activity are still not well understood, and the role of specific ion channels in these processes remains unclear. Here we introduce the flatworm Macrostomum lignano as a versatile model organism for addressing these topics. We discuss biological and experimental properties of M. lignano, provide an overview of the recently developed experimental tools for this animal model, and demonstrate how manipulation of membrane potential influences regeneration in M. lignano.http://dx.doi.org/10.1155/2012/167265 |
| spellingShingle | Daniil Simanov Imre Mellaart-Straver Irina Sormacheva Eugene Berezikov The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research Stem Cells International |
| title | The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research |
| title_full | The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research |
| title_fullStr | The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research |
| title_full_unstemmed | The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research |
| title_short | The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research |
| title_sort | flatworm macrostomum lignano is a powerful model organism for ion channel and stem cell research |
| url | http://dx.doi.org/10.1155/2012/167265 |
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