The role of interleukin-17 in inflammation-related cancers
Emerging evidence indicates a correlation between inflammation and the development and progression of cancer. Among the various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as a critical link between inflammation and cancer. IL-17 is a highly versatile pro-inflammatory cytokin...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479505/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592441403768832 |
|---|---|
| author | Xingru Zhang Xingru Zhang Bangjie Li Tian Lan Tian Lan Conner Chiari Xiaoyang Ye Kepeng Wang Ju Chen |
| author_facet | Xingru Zhang Xingru Zhang Bangjie Li Tian Lan Tian Lan Conner Chiari Xiaoyang Ye Kepeng Wang Ju Chen |
| author_sort | Xingru Zhang |
| collection | DOAJ |
| description | Emerging evidence indicates a correlation between inflammation and the development and progression of cancer. Among the various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as a critical link between inflammation and cancer. IL-17 is a highly versatile pro-inflammatory cytokine that plays a pivotal role in host defense, tissue repair, the pathogenesis of inflammatory diseases, and cancer progression. During the early stages of tumorigenesis, IL-17 signaling directly promotes the proliferation of tumor cells. Conversely, IL-17 has been shown to exhibit antitumor immunity in several models of grafted subcutaneous tumors. Additionally, dynamic changes in the microbiome can influence the secretion of IL-17, thereby affecting tumor development. The specific role of IL-17 is contingent upon its functional classification, spatiotemporal characteristics, and the stage of tumor development. In this review, we introduce the fundamental biology of IL-17 and the expression profile of its receptors in cancer, while also reviewing and discussing recent advancements regarding the pleiotropic effects and mechanisms of IL-17 in inflammation-related cancers. Furthermore, we supplement our discussion with insights into the mechanisms by which IL-17 impacts cancer progression through interactions with the microbiota, and we explore the implications of IL-17 in cancer therapy. This comprehensive analysis aims to enhance our understanding of IL-17 and its potential role in cancer treatment. |
| format | Article |
| id | doaj-art-ef232c1c29454d349f6d28131f671fd4 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ef232c1c29454d349f6d28131f671fd42025-01-21T08:36:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14795051479505The role of interleukin-17 in inflammation-related cancersXingru Zhang0Xingru Zhang1Bangjie Li2Tian Lan3Tian Lan4Conner Chiari5Xiaoyang Ye6Kepeng Wang7Ju Chen8The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, ChinaDepartment of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, ChinaThe Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, ChinaThe Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, ChinaDepartment of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, ChinaDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, United StatesCollege of Engineering, Northeastern University, Seattle, WA, United StatesDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, United StatesThe Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, ChinaEmerging evidence indicates a correlation between inflammation and the development and progression of cancer. Among the various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as a critical link between inflammation and cancer. IL-17 is a highly versatile pro-inflammatory cytokine that plays a pivotal role in host defense, tissue repair, the pathogenesis of inflammatory diseases, and cancer progression. During the early stages of tumorigenesis, IL-17 signaling directly promotes the proliferation of tumor cells. Conversely, IL-17 has been shown to exhibit antitumor immunity in several models of grafted subcutaneous tumors. Additionally, dynamic changes in the microbiome can influence the secretion of IL-17, thereby affecting tumor development. The specific role of IL-17 is contingent upon its functional classification, spatiotemporal characteristics, and the stage of tumor development. In this review, we introduce the fundamental biology of IL-17 and the expression profile of its receptors in cancer, while also reviewing and discussing recent advancements regarding the pleiotropic effects and mechanisms of IL-17 in inflammation-related cancers. Furthermore, we supplement our discussion with insights into the mechanisms by which IL-17 impacts cancer progression through interactions with the microbiota, and we explore the implications of IL-17 in cancer therapy. This comprehensive analysis aims to enhance our understanding of IL-17 and its potential role in cancer treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479505/fullinterleukin-17cancerinflammationtumor microenvironmentimmunotherapy |
| spellingShingle | Xingru Zhang Xingru Zhang Bangjie Li Tian Lan Tian Lan Conner Chiari Xiaoyang Ye Kepeng Wang Ju Chen The role of interleukin-17 in inflammation-related cancers Frontiers in Immunology interleukin-17 cancer inflammation tumor microenvironment immunotherapy |
| title | The role of interleukin-17 in inflammation-related cancers |
| title_full | The role of interleukin-17 in inflammation-related cancers |
| title_fullStr | The role of interleukin-17 in inflammation-related cancers |
| title_full_unstemmed | The role of interleukin-17 in inflammation-related cancers |
| title_short | The role of interleukin-17 in inflammation-related cancers |
| title_sort | role of interleukin 17 in inflammation related cancers |
| topic | interleukin-17 cancer inflammation tumor microenvironment immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1479505/full |
| work_keys_str_mv | AT xingruzhang theroleofinterleukin17ininflammationrelatedcancers AT xingruzhang theroleofinterleukin17ininflammationrelatedcancers AT bangjieli theroleofinterleukin17ininflammationrelatedcancers AT tianlan theroleofinterleukin17ininflammationrelatedcancers AT tianlan theroleofinterleukin17ininflammationrelatedcancers AT connerchiari theroleofinterleukin17ininflammationrelatedcancers AT xiaoyangye theroleofinterleukin17ininflammationrelatedcancers AT kepengwang theroleofinterleukin17ininflammationrelatedcancers AT juchen theroleofinterleukin17ininflammationrelatedcancers AT xingruzhang roleofinterleukin17ininflammationrelatedcancers AT xingruzhang roleofinterleukin17ininflammationrelatedcancers AT bangjieli roleofinterleukin17ininflammationrelatedcancers AT tianlan roleofinterleukin17ininflammationrelatedcancers AT tianlan roleofinterleukin17ininflammationrelatedcancers AT connerchiari roleofinterleukin17ininflammationrelatedcancers AT xiaoyangye roleofinterleukin17ininflammationrelatedcancers AT kepengwang roleofinterleukin17ininflammationrelatedcancers AT juchen roleofinterleukin17ininflammationrelatedcancers |