Cortical Reorganization following Injury Early in Life
The brain has a remarkable capacity for reorganization following injury, especially during the first years of life. Knowledge of structural reorganization and its consequences following perinatal injury is sparse. Here we studied changes in brain tissue volume, morphology, perfusion, and integrity i...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8615872 |
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| _version_ | 1832563671522344960 |
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| author | Moran Artzi Shelly Irene Shiran Maya Weinstein Vicki Myers Ricardo Tarrasch Mitchell Schertz Aviva Fattal-Valevski Elka Miller Andrew M. Gordon Dido Green Dafna Ben Bashat |
| author_facet | Moran Artzi Shelly Irene Shiran Maya Weinstein Vicki Myers Ricardo Tarrasch Mitchell Schertz Aviva Fattal-Valevski Elka Miller Andrew M. Gordon Dido Green Dafna Ben Bashat |
| author_sort | Moran Artzi |
| collection | DOAJ |
| description | The brain has a remarkable capacity for reorganization following injury, especially during the first years of life. Knowledge of structural reorganization and its consequences following perinatal injury is sparse. Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI. Children with hemiplegia demonstrated reduced total cerebral volume, with increased cerebrospinal fluid (CSF) and reduced total white matter volumes, with no differences in total gray matter volume, compared to typically developing children. An increase in cortical thickness at the hemisphere contralateral to the lesion (CLH) was detected in motor and language areas, which may reflect compensation for the gray matter loss in the lesion area or retention of ipsilateral pathways. In addition, reduced cortical thickness, perfusion, and surface area were detected in limbic areas. Increased CSF volume and precentral cortical thickness and reduced white matter volume were correlated with worse motor performance. Brain reorganization of the gray matter within the CLH, while not necessarily indicating better outcome, is suggested as a response to neuronal deficits following injury early in life. |
| format | Article |
| id | doaj-art-ef16e4015c80475ab168ddaa80e6a514 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ef16e4015c80475ab168ddaa80e6a5142025-02-03T01:12:57ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/86158728615872Cortical Reorganization following Injury Early in LifeMoran Artzi0Shelly Irene Shiran1Maya Weinstein2Vicki Myers3Ricardo Tarrasch4Mitchell Schertz5Aviva Fattal-Valevski6Elka Miller7Andrew M. Gordon8Dido Green9Dafna Ben Bashat10Functional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, IsraelDepartment of Radiology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, IsraelFunctional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, IsraelFunctional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, IsraelJaime and Joan Constantiner School of Education, Tel Aviv University, P.O. Box 39040, 69978 Tel Aviv, IsraelPaediatric Neurology Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDiagnostic Imaging, Children’s Hospital of Eastern Ontario, 401 Smyth Road Ottawa, ON, K1H 8L1, CanadaDepartment of Biobehavioral Sciences, Teachers College, Columbia University, 525 W 120th Street, New York, NY 10027, USADepartment Occupational Therapy, Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelFunctional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, IsraelThe brain has a remarkable capacity for reorganization following injury, especially during the first years of life. Knowledge of structural reorganization and its consequences following perinatal injury is sparse. Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI. Children with hemiplegia demonstrated reduced total cerebral volume, with increased cerebrospinal fluid (CSF) and reduced total white matter volumes, with no differences in total gray matter volume, compared to typically developing children. An increase in cortical thickness at the hemisphere contralateral to the lesion (CLH) was detected in motor and language areas, which may reflect compensation for the gray matter loss in the lesion area or retention of ipsilateral pathways. In addition, reduced cortical thickness, perfusion, and surface area were detected in limbic areas. Increased CSF volume and precentral cortical thickness and reduced white matter volume were correlated with worse motor performance. Brain reorganization of the gray matter within the CLH, while not necessarily indicating better outcome, is suggested as a response to neuronal deficits following injury early in life.http://dx.doi.org/10.1155/2016/8615872 |
| spellingShingle | Moran Artzi Shelly Irene Shiran Maya Weinstein Vicki Myers Ricardo Tarrasch Mitchell Schertz Aviva Fattal-Valevski Elka Miller Andrew M. Gordon Dido Green Dafna Ben Bashat Cortical Reorganization following Injury Early in Life Neural Plasticity |
| title | Cortical Reorganization following Injury Early in Life |
| title_full | Cortical Reorganization following Injury Early in Life |
| title_fullStr | Cortical Reorganization following Injury Early in Life |
| title_full_unstemmed | Cortical Reorganization following Injury Early in Life |
| title_short | Cortical Reorganization following Injury Early in Life |
| title_sort | cortical reorganization following injury early in life |
| url | http://dx.doi.org/10.1155/2016/8615872 |
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