Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis
Background and Objectives. Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes. Methods. The study group comprised 38 patients with UC in clinical r...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/192794 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566725558665216 |
|---|---|
| author | Kaoru Yokoyama Kiyonori Kobayashi Miyuki Mukae Miwa Sada Wasaburo Koizumi |
| author_facet | Kaoru Yokoyama Kiyonori Kobayashi Miyuki Mukae Miwa Sada Wasaburo Koizumi |
| author_sort | Kaoru Yokoyama |
| collection | DOAJ |
| description | Background and Objectives. Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes. Methods. The study group comprised 38 patients with UC in clinical remission on total colonoscopy who were followed up for at least 5 years. Clinical remission was defined as a Mayo score of 0 for both stool frequency and rectal bleeding. Colonoscopic findings were evaluated into 4 grades according to the Mayo endoscopic subscore (MES). Results. During clinical remission, the MES was 0 in only 24% of the patients, 1 in 40%, 2 in 26%, and 3 in 10%. Seventy-six percent of the patients thus had active disease on colonoscopy. After initial colonoscopy, the cumulative rate of remission maintenance was 100% in MES 0, 1 in 93%, 2 in 70%, and 3 in 50% at 6 months and 78%, 40%, 10%, and 0%, respectively, at 5 years (). Conclusion. Many patients with UC in clinical remission have active lesions. Patients with a higher MES have a higher rate of recurrence. To improve long-term outcomes, an MES of 0 should be the treatment goal. |
| format | Article |
| id | doaj-art-ef169c3bddb64b0b98bb9846d64bf346 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ef169c3bddb64b0b98bb9846d64bf3462025-02-03T01:03:25ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/192794192794Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative ColitisKaoru Yokoyama0Kiyonori Kobayashi1Miyuki Mukae2Miwa Sada3Wasaburo Koizumi4Department of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Minami, Sagamihara 252-0380, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Minami, Sagamihara 252-0380, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Minami, Sagamihara 252-0380, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Minami, Sagamihara 252-0380, JapanDepartment of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Minami, Sagamihara 252-0380, JapanBackground and Objectives. Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes. Methods. The study group comprised 38 patients with UC in clinical remission on total colonoscopy who were followed up for at least 5 years. Clinical remission was defined as a Mayo score of 0 for both stool frequency and rectal bleeding. Colonoscopic findings were evaluated into 4 grades according to the Mayo endoscopic subscore (MES). Results. During clinical remission, the MES was 0 in only 24% of the patients, 1 in 40%, 2 in 26%, and 3 in 10%. Seventy-six percent of the patients thus had active disease on colonoscopy. After initial colonoscopy, the cumulative rate of remission maintenance was 100% in MES 0, 1 in 93%, 2 in 70%, and 3 in 50% at 6 months and 78%, 40%, 10%, and 0%, respectively, at 5 years (). Conclusion. Many patients with UC in clinical remission have active lesions. Patients with a higher MES have a higher rate of recurrence. To improve long-term outcomes, an MES of 0 should be the treatment goal.http://dx.doi.org/10.1155/2013/192794 |
| spellingShingle | Kaoru Yokoyama Kiyonori Kobayashi Miyuki Mukae Miwa Sada Wasaburo Koizumi Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis Gastroenterology Research and Practice |
| title | Clinical Study of the Relation between Mucosal Healing and
Long-Term Outcomes in Ulcerative Colitis |
| title_full | Clinical Study of the Relation between Mucosal Healing and
Long-Term Outcomes in Ulcerative Colitis |
| title_fullStr | Clinical Study of the Relation between Mucosal Healing and
Long-Term Outcomes in Ulcerative Colitis |
| title_full_unstemmed | Clinical Study of the Relation between Mucosal Healing and
Long-Term Outcomes in Ulcerative Colitis |
| title_short | Clinical Study of the Relation between Mucosal Healing and
Long-Term Outcomes in Ulcerative Colitis |
| title_sort | clinical study of the relation between mucosal healing and long term outcomes in ulcerative colitis |
| url | http://dx.doi.org/10.1155/2013/192794 |
| work_keys_str_mv | AT kaoruyokoyama clinicalstudyoftherelationbetweenmucosalhealingandlongtermoutcomesinulcerativecolitis AT kiyonorikobayashi clinicalstudyoftherelationbetweenmucosalhealingandlongtermoutcomesinulcerativecolitis AT miyukimukae clinicalstudyoftherelationbetweenmucosalhealingandlongtermoutcomesinulcerativecolitis AT miwasada clinicalstudyoftherelationbetweenmucosalhealingandlongtermoutcomesinulcerativecolitis AT wasaburokoizumi clinicalstudyoftherelationbetweenmucosalhealingandlongtermoutcomesinulcerativecolitis |