Exosomal delivery of IL-10: Biodistribution, pharmacokinetics, and preterm birth prevention strategies

Exosomal delivery of IL-10: Biodistribution, pharmacokinetics, and preterm birth prevention strategies

This study investigates the potential of extracellular vesicles (EVs) loaded with interleukin-10 (IL-10) to reduce infection-induced preterm birth (PTB). IL-10 has shown promise in reducing PTB by dampening inflammatory responses, but challenges exist with intraamniotic administration. The study eva...

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Bibliographic Details
Main Authors: Brinley Harrington, Tilu Jain Thomas, Madhuri Tatiparthy, Awanit Kumar, Lauren Richardson, Ramkumar Menon, Ananth Kumar Kammala
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Extracellular Vesicle
Subjects:
IL-10
Bioequivalence
Pregnancy
Ascending infection
Transfection
Electroporation
Online Access:http://www.sciencedirect.com/science/article/pii/S2773041725000022
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