Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.
A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV in...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-08-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1004345 |
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| author | Nichole R Klatt Steven E Bosinger Melicent Peck Laura E Richert-Spuhler Anke Heigele Jillian P Gile Nirav Patel Jessica Taaffe Boris Julg David Camerini Carlo Torti Jeffrey N Martin Steven G Deeks Elizabeth Sinclair Frederick M Hecht Michael M Lederman Mirko Paiardini Frank Kirchhoff Jason M Brenchley Peter W Hunt Guido Silvestri |
| author_facet | Nichole R Klatt Steven E Bosinger Melicent Peck Laura E Richert-Spuhler Anke Heigele Jillian P Gile Nirav Patel Jessica Taaffe Boris Julg David Camerini Carlo Torti Jeffrey N Martin Steven G Deeks Elizabeth Sinclair Frederick M Hecht Michael M Lederman Mirko Paiardini Frank Kirchhoff Jason M Brenchley Peter W Hunt Guido Silvestri |
| author_sort | Nichole R Klatt |
| collection | DOAJ |
| description | A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated ("putative progressors", PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (TSCM (p<0.0001), which was associated with decreased HIV infection of these cells in VNPs (r = -0.649, p = 0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (TCM) cells (p = 0.035), and the total number of TCM cells was associated with increased proliferation of memory CD4+ T cells (r = 0.733, p = 0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ TCM and TSCM, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia. |
| format | Article |
| id | doaj-art-eef74e25784f450da0159e4e5b448876 |
| institution | DOAJ |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-eef74e25784f450da0159e4e5b4488762025-08-20T03:12:34ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742014-08-01108e100434510.1371/journal.ppat.1004345Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.Nichole R KlattSteven E BosingerMelicent PeckLaura E Richert-SpuhlerAnke HeigeleJillian P GileNirav PatelJessica TaaffeBoris JulgDavid CameriniCarlo TortiJeffrey N MartinSteven G DeeksElizabeth SinclairFrederick M HechtMichael M LedermanMirko PaiardiniFrank KirchhoffJason M BrenchleyPeter W HuntGuido SilvestriA rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated ("putative progressors", PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (TSCM (p<0.0001), which was associated with decreased HIV infection of these cells in VNPs (r = -0.649, p = 0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (TCM) cells (p = 0.035), and the total number of TCM cells was associated with increased proliferation of memory CD4+ T cells (r = 0.733, p = 0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ TCM and TSCM, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia.https://doi.org/10.1371/journal.ppat.1004345 |
| spellingShingle | Nichole R Klatt Steven E Bosinger Melicent Peck Laura E Richert-Spuhler Anke Heigele Jillian P Gile Nirav Patel Jessica Taaffe Boris Julg David Camerini Carlo Torti Jeffrey N Martin Steven G Deeks Elizabeth Sinclair Frederick M Hecht Michael M Lederman Mirko Paiardini Frank Kirchhoff Jason M Brenchley Peter W Hunt Guido Silvestri Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. PLoS Pathogens |
| title | Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. |
| title_full | Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. |
| title_fullStr | Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. |
| title_full_unstemmed | Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. |
| title_short | Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. |
| title_sort | limited hiv infection of central memory and stem cell memory cd4 t cells is associated with lack of progression in viremic individuals |
| url | https://doi.org/10.1371/journal.ppat.1004345 |
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