Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study
Background: Ankle-foot sprains are the most common musculoskeletal injuries, which can impair balance and theoretically increase the risk of falls, but still, there is a lack of evidence supporting the direct association between ankle-foot sprains and the future risk of falls. Methods: UK Biobank co...
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Sports Medicine and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266633762400060X |
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| author | Xiao'ao Xue Weichu Tao Qianru Li Yi Li Yiran Wang Le Yu Xicheng Gu Tian Xia Rong Lu Ru Wang He Wang Yinghui Hua |
| author_facet | Xiao'ao Xue Weichu Tao Qianru Li Yi Li Yiran Wang Le Yu Xicheng Gu Tian Xia Rong Lu Ru Wang He Wang Yinghui Hua |
| author_sort | Xiao'ao Xue |
| collection | DOAJ |
| description | Background: Ankle-foot sprains are the most common musculoskeletal injuries, which can impair balance and theoretically increase the risk of falls, but still, there is a lack of evidence supporting the direct association between ankle-foot sprains and the future risk of falls. Methods: UK Biobank cohort was utilized to measure the association between ankle-foot sprains and fall risk with covariates adjusted. Then, the two-sample Mendelian randomization (MR) analysis was applied based on the genetically predicated ankle-foot sprains from FinnGen to validate causal relationship. Finally, genetically predicated cerebellar neuroimaging features were used to explore the mediating role of maladaptive neuroplasticity between ankle-foot sprains and falls by two-step MR analyses. Results: Patients with ankle-foot sprains history exhibited a slightly increased risk of falls than the matched controls before and after adjustment for covariates (odd ratio [OR] ranged from 1.632 to 1.658). Two-sample MR analysis showed that ankle-foot sprains led to a higher risk of falls (OR = 1.036) and a lower fractional anisotropy of superior cerebellar peduncle (SCP) (left, β = −0.052; right, β = −0.053). A trend of mediating effect was observed for the fractional anisotropy of right SCP in the causal effects of ankle-foot sprains on falls (β = 0.003). Conclusion: The history of ankle-foot sprains is associated with a slightly increased risk of falls. These findings improve our understanding of the clinical consequences of ankle-foot sprains in terms of fall risk and suggest the importance of adopting more efficient strategies for managing residual functional deficits after the injuries. |
| format | Article |
| id | doaj-art-eef4f83b9bd64c77aafb2f3f2b48696a |
| institution | Kabale University |
| issn | 2666-3376 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sports Medicine and Health Science |
| spelling | doaj-art-eef4f83b9bd64c77aafb2f3f2b48696a2025-02-01T04:12:00ZengKeAi Communications Co., Ltd.Sports Medicine and Health Science2666-33762025-05-0173214223Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization studyXiao'ao Xue0Weichu Tao1Qianru Li2Yi Li3Yiran Wang4Le Yu5Xicheng Gu6Tian Xia7Rong Lu8Ru Wang9He Wang10Yinghui Hua11Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China; Corresponding author. School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; Human Phenome Institute, Fudan University, Shanghai, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China; Corresponding author. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 201203, China.Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China; Corresponding author. 12 Wulumuqi Middle Road, Department of Sports Medicine, Huashan Hospital, Shanghai, 200040, China.Background: Ankle-foot sprains are the most common musculoskeletal injuries, which can impair balance and theoretically increase the risk of falls, but still, there is a lack of evidence supporting the direct association between ankle-foot sprains and the future risk of falls. Methods: UK Biobank cohort was utilized to measure the association between ankle-foot sprains and fall risk with covariates adjusted. Then, the two-sample Mendelian randomization (MR) analysis was applied based on the genetically predicated ankle-foot sprains from FinnGen to validate causal relationship. Finally, genetically predicated cerebellar neuroimaging features were used to explore the mediating role of maladaptive neuroplasticity between ankle-foot sprains and falls by two-step MR analyses. Results: Patients with ankle-foot sprains history exhibited a slightly increased risk of falls than the matched controls before and after adjustment for covariates (odd ratio [OR] ranged from 1.632 to 1.658). Two-sample MR analysis showed that ankle-foot sprains led to a higher risk of falls (OR = 1.036) and a lower fractional anisotropy of superior cerebellar peduncle (SCP) (left, β = −0.052; right, β = −0.053). A trend of mediating effect was observed for the fractional anisotropy of right SCP in the causal effects of ankle-foot sprains on falls (β = 0.003). Conclusion: The history of ankle-foot sprains is associated with a slightly increased risk of falls. These findings improve our understanding of the clinical consequences of ankle-foot sprains in terms of fall risk and suggest the importance of adopting more efficient strategies for managing residual functional deficits after the injuries.http://www.sciencedirect.com/science/article/pii/S266633762400060XLeg injuriesAccidental fallsPostural balanceMendelian randomization analysisUK biobankFinnGen |
| spellingShingle | Xiao'ao Xue Weichu Tao Qianru Li Yi Li Yiran Wang Le Yu Xicheng Gu Tian Xia Rong Lu Ru Wang He Wang Yinghui Hua Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study Sports Medicine and Health Science Leg injuries Accidental falls Postural balance Mendelian randomization analysis UK biobank FinnGen |
| title | Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study |
| title_full | Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study |
| title_fullStr | Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study |
| title_full_unstemmed | Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study |
| title_short | Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study |
| title_sort | future risk of falls induced by ankle foot sprains history an observational and mendelian randomization study |
| topic | Leg injuries Accidental falls Postural balance Mendelian randomization analysis UK biobank FinnGen |
| url | http://www.sciencedirect.com/science/article/pii/S266633762400060X |
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