Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples

Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples

Acute leukemia represents the most common pediatric malignancy comprising diverse subtypes with varying prognosis and treatment outcomes. New and targeted treatment options are warranted for this disease. Patient-derived xenograft (PDX) models are increasingly being used for preclinical testing of n...

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Bibliographic Details
Main Authors: Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey
Format: Article
Language:English
Published: BioMed Central 2020-03-01
Series:Genomics & Informatics
Subjects:
error-corrected sequencing
genomics
patient derived xenograft models
pediatric cancers
structural variants
Online Access:http://genominfo.org/upload/pdf/gi-2020-18-1-e6.pdf
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http://genominfo.org/upload/pdf/gi-2020-18-1-e6.pdf

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