Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages
Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamste...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/950303 |
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| author | Jeanette Prada-Arismendy Verónica Rincón Jaime E. Castellanos |
| author_facet | Jeanette Prada-Arismendy Verónica Rincón Jaime E. Castellanos |
| author_sort | Jeanette Prada-Arismendy |
| collection | DOAJ |
| description | Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 (DENV2). The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. Other molecular mechanisms related to flavivirus susceptibility remain to be explored. |
| format | Article |
| id | doaj-art-eee2328ee06247e4b98d55cd9ee5ad18 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-eee2328ee06247e4b98d55cd9ee5ad182025-02-03T01:23:46ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/950303950303Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent MacrophagesJeanette Prada-Arismendy0Verónica Rincón1Jaime E. Castellanos2Instituto de Virología, Universidad El Bosque, Carrera 7B Bis No. 132-11, Bogotá, ColombiaInstituto de Virología, Universidad El Bosque, Carrera 7B Bis No. 132-11, Bogotá, ColombiaInstituto de Virología, Universidad El Bosque, Carrera 7B Bis No. 132-11, Bogotá, ColombiaInfection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 (DENV2). The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. Other molecular mechanisms related to flavivirus susceptibility remain to be explored.http://dx.doi.org/10.1155/2012/950303 |
| spellingShingle | Jeanette Prada-Arismendy Verónica Rincón Jaime E. Castellanos Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages Journal of Tropical Medicine |
| title | Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages |
| title_full | Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages |
| title_fullStr | Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages |
| title_full_unstemmed | Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages |
| title_short | Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages |
| title_sort | comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages |
| url | http://dx.doi.org/10.1155/2012/950303 |
| work_keys_str_mv | AT jeanettepradaarismendy comparativeevaluationofpermissivenesstodenguevirusserotype2infectioninprimaryrodentmacrophages AT veronicarincon comparativeevaluationofpermissivenesstodenguevirusserotype2infectioninprimaryrodentmacrophages AT jaimeecastellanos comparativeevaluationofpermissivenesstodenguevirusserotype2infectioninprimaryrodentmacrophages |