Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities
This article describes the synthesis of curcumin complexes with metal ions. Properties of these complexes such as spectra IR and UV-Vis and solubility were investigated. The optimum parameters of ultrasound to enhance the solubility was figured out as follows: the capacity of ultrasound: 750 W/g; th...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/8082195 |
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| _version_ | 1832554926966833152 |
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| author | Tran Quang Hieu Doan Thi Thanh Thao |
| author_facet | Tran Quang Hieu Doan Thi Thanh Thao |
| author_sort | Tran Quang Hieu |
| collection | DOAJ |
| description | This article describes the synthesis of curcumin complexes with metal ions. Properties of these complexes such as spectra IR and UV-Vis and solubility were investigated. The optimum parameters of ultrasound to enhance the solubility was figured out as follows: the capacity of ultrasound: 750 W/g; the time of ultrasound: 7 min; the concentration of the surfactant Tween 80 : 2%. The maximum solubility (mg/ml) of complexes was as follows: Cur-Fe(III): 0.162 ± 0.01; Cur-Zn(II): 0.267 ± 0.02; and Cur-Ca(II): 0.417 ± 0.05. Antioxidant capacity (DPPH, %I) of curcumin complexes was higher than that of curcumin-free complexes. All of these curcumin complexes revealed antimicrobial activities, in which calcium complex had the best resistance against Salmonella, followed by Fe(III) complexes. Meanwhile, the zinc complex was not resistant to this bacterium. These complexes showed antibacterial activity on Staphylococcus aureus, in which Cur-Ca (II) complexes had the highest antibacterial activity. For Escherichia coli, the Cur-Zn (II) complex had no resistance, while the Cur-Ca (II) complex showed the highest antibacterial activity. |
| format | Article |
| id | doaj-art-eecf868a109d4baba7f7547d139a3a1e |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-eecf868a109d4baba7f7547d139a3a1e2025-02-03T05:50:12ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/80821958082195Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological ActivitiesTran Quang Hieu0Doan Thi Thanh Thao1Department of Chemistry, Basic Sciences Department, Saigon Technology University, Ho Chi Minh City 700000, VietnamDepartment of Chemistry, Basic Sciences Department, Saigon Technology University, Ho Chi Minh City 700000, VietnamThis article describes the synthesis of curcumin complexes with metal ions. Properties of these complexes such as spectra IR and UV-Vis and solubility were investigated. The optimum parameters of ultrasound to enhance the solubility was figured out as follows: the capacity of ultrasound: 750 W/g; the time of ultrasound: 7 min; the concentration of the surfactant Tween 80 : 2%. The maximum solubility (mg/ml) of complexes was as follows: Cur-Fe(III): 0.162 ± 0.01; Cur-Zn(II): 0.267 ± 0.02; and Cur-Ca(II): 0.417 ± 0.05. Antioxidant capacity (DPPH, %I) of curcumin complexes was higher than that of curcumin-free complexes. All of these curcumin complexes revealed antimicrobial activities, in which calcium complex had the best resistance against Salmonella, followed by Fe(III) complexes. Meanwhile, the zinc complex was not resistant to this bacterium. These complexes showed antibacterial activity on Staphylococcus aureus, in which Cur-Ca (II) complexes had the highest antibacterial activity. For Escherichia coli, the Cur-Zn (II) complex had no resistance, while the Cur-Ca (II) complex showed the highest antibacterial activity.http://dx.doi.org/10.1155/2019/8082195 |
| spellingShingle | Tran Quang Hieu Doan Thi Thanh Thao Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities Journal of Chemistry |
| title | Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities |
| title_full | Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities |
| title_fullStr | Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities |
| title_full_unstemmed | Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities |
| title_short | Enhancing the Solubility of Curcumin Metal Complexes and Investigating Some of Their Biological Activities |
| title_sort | enhancing the solubility of curcumin metal complexes and investigating some of their biological activities |
| url | http://dx.doi.org/10.1155/2019/8082195 |
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