Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer
Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2016/3010934 |
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| author | Gopinath Thilak Parepady Sundar Vishwanath Sherigar Sameep S. Shetty Shree Satya Sourabh M. Gohil |
| author_facet | Gopinath Thilak Parepady Sundar Vishwanath Sherigar Sameep S. Shetty Shree Satya Sourabh M. Gohil |
| author_sort | Gopinath Thilak Parepady Sundar |
| collection | DOAJ |
| description | Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread. |
| format | Article |
| id | doaj-art-eecb6e156ab64a638d80de28d7288fa1 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-eecb6e156ab64a638d80de28d7288fa12025-02-03T06:46:17ZengWileyCase Reports in Dentistry2090-64472090-64552016-01-01201610.1155/2016/30109343010934Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral CancerGopinath Thilak Parepady Sundar0Vishwanath Sherigar1Sameep S. Shetty2Shree Satya3Sourabh M. Gohil4Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, IndiaK.S. Hegde Charitable Hospital, Mangalore, IndiaDepartment of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal University, Manipal, IndiaDepartment of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, IndiaDepartment of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, IndiaPerineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.http://dx.doi.org/10.1155/2016/3010934 |
| spellingShingle | Gopinath Thilak Parepady Sundar Vishwanath Sherigar Sameep S. Shetty Shree Satya Sourabh M. Gohil Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer Case Reports in Dentistry |
| title | Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer |
| title_full | Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer |
| title_fullStr | Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer |
| title_full_unstemmed | Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer |
| title_short | Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer |
| title_sort | mandibular canal widening and bell s palsy sequelae of perineural invasion in oral cancer |
| url | http://dx.doi.org/10.1155/2016/3010934 |
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