Extended-Interval Gentamicin Dosing for Pulmonic Tularemia
Francisella tularensis is a Gram-negative coccobacillus that is rarely encountered in clinical practice. Patients can present with cutaneous, pulmonary, cardiac, mucous membrane, or gastrointestinal involvement. A clinician should have a heightened suspicion in endemic areas or when outbreaks appear...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/9870510 |
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| _version_ | 1832565546946658304 |
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| author | Tyson Dietrich Katelynn Garcia Joe Strain John Ashurst |
| author_facet | Tyson Dietrich Katelynn Garcia Joe Strain John Ashurst |
| author_sort | Tyson Dietrich |
| collection | DOAJ |
| description | Francisella tularensis is a Gram-negative coccobacillus that is rarely encountered in clinical practice. Patients can present with cutaneous, pulmonary, cardiac, mucous membrane, or gastrointestinal involvement. A clinician should have a heightened suspicion in endemic areas or when outbreaks appear. Diagnosis is achieved through serological testing or polymerase chain reaction assays. Although historically the treatment of choice was streptomycin, gentamicin is now preferred due to its availability and relatively safer side effect profile with extended-interval dosing. Limited published evidence exists on the effectiveness of extended-interval gentamicin for tularemia. This case series describes four patients with pulmonic tularemia successfully treated with extended-interval dosing of gentamicin without treatment failure or relapse. |
| format | Article |
| id | doaj-art-eec745dd625e4fef9b257a1850a9b373 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-eec745dd625e4fef9b257a1850a9b3732025-02-03T01:07:20ZengWileyCase Reports in Infectious Diseases2090-66252090-66332019-01-01201910.1155/2019/98705109870510Extended-Interval Gentamicin Dosing for Pulmonic TularemiaTyson Dietrich0Katelynn Garcia1Joe Strain2John Ashurst3Kingman Regional Medical Center, Department of Pharmacy, 3269 Stockton Hill Road, Kingman, AZ 86409, USARegional Health Rapid City Hospital, Department of Pharmacy, 353 Fairmont Blvd, Rapid City, SD 57701, USAKingman Regional Medical Center, Department of Emergency Medicine, 3269 Stockton Hill Road, Kingman, AZ 86409, USAKingman Regional Medical Center, Department of Emergency Medicine, 3269 Stockton Hill Road, Kingman, AZ 86409, USAFrancisella tularensis is a Gram-negative coccobacillus that is rarely encountered in clinical practice. Patients can present with cutaneous, pulmonary, cardiac, mucous membrane, or gastrointestinal involvement. A clinician should have a heightened suspicion in endemic areas or when outbreaks appear. Diagnosis is achieved through serological testing or polymerase chain reaction assays. Although historically the treatment of choice was streptomycin, gentamicin is now preferred due to its availability and relatively safer side effect profile with extended-interval dosing. Limited published evidence exists on the effectiveness of extended-interval gentamicin for tularemia. This case series describes four patients with pulmonic tularemia successfully treated with extended-interval dosing of gentamicin without treatment failure or relapse.http://dx.doi.org/10.1155/2019/9870510 |
| spellingShingle | Tyson Dietrich Katelynn Garcia Joe Strain John Ashurst Extended-Interval Gentamicin Dosing for Pulmonic Tularemia Case Reports in Infectious Diseases |
| title | Extended-Interval Gentamicin Dosing for Pulmonic Tularemia |
| title_full | Extended-Interval Gentamicin Dosing for Pulmonic Tularemia |
| title_fullStr | Extended-Interval Gentamicin Dosing for Pulmonic Tularemia |
| title_full_unstemmed | Extended-Interval Gentamicin Dosing for Pulmonic Tularemia |
| title_short | Extended-Interval Gentamicin Dosing for Pulmonic Tularemia |
| title_sort | extended interval gentamicin dosing for pulmonic tularemia |
| url | http://dx.doi.org/10.1155/2019/9870510 |
| work_keys_str_mv | AT tysondietrich extendedintervalgentamicindosingforpulmonictularemia AT katelynngarcia extendedintervalgentamicindosingforpulmonictularemia AT joestrain extendedintervalgentamicindosingforpulmonictularemia AT johnashurst extendedintervalgentamicindosingforpulmonictularemia |