Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients w...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2021/2838669 |
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| author | Afnan AwadAllah Elgnainy Mohammad Ismail Hamed Wael Osman Mohamed Nagwa Ali Sabri |
| author_facet | Afnan AwadAllah Elgnainy Mohammad Ismail Hamed Wael Osman Mohamed Nagwa Ali Sabri |
| author_sort | Afnan AwadAllah Elgnainy |
| collection | DOAJ |
| description | Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson’s Disease Rating Scale (UPDRS) part IV. Results. Diabetics recorded higher scores of RBDSQ than controls (p<0.001), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 (p<0.001) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p=0.013). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS (p<0.001). Conclusion. Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357. |
| format | Article |
| id | doaj-art-eec2931688524da2ad065450c5fdfc16 |
| institution | Kabale University |
| issn | 2090-1860 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-eec2931688524da2ad065450c5fdfc162025-02-03T06:44:02ZengWileyNeurology Research International2090-18602021-01-01202110.1155/2021/2838669Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot StudyAfnan AwadAllah Elgnainy0Mohammad Ismail Hamed1Wael Osman Mohamed2Nagwa Ali Sabri3Department of Clinical PharmacyDepartment of Clinical PharmacyDepartment of NeurologyDepartment of Clinical PharmacyObjectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson’s Disease Rating Scale (UPDRS) part IV. Results. Diabetics recorded higher scores of RBDSQ than controls (p<0.001), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 (p<0.001) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p=0.013). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS (p<0.001). Conclusion. Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357.http://dx.doi.org/10.1155/2021/2838669 |
| spellingShingle | Afnan AwadAllah Elgnainy Mohammad Ismail Hamed Wael Osman Mohamed Nagwa Ali Sabri Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study Neurology Research International |
| title | Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study |
| title_full | Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study |
| title_fullStr | Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study |
| title_full_unstemmed | Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study |
| title_short | Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study |
| title_sort | investigation of the possible correlation between idiopathic parkinson s disease and diabetes mellitus in egyptian patients a pilot study |
| url | http://dx.doi.org/10.1155/2021/2838669 |
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