Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration
Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed b...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/342701 |
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| author | Hanene ELjebari Nadia Ben Fradj Issam Salouage Emna Gaies Sameh Trabelsi Nadia Jebabli Mohamed Lakhal Tarek Ben Othman Anis Kouz |
| author_facet | Hanene ELjebari Nadia Ben Fradj Issam Salouage Emna Gaies Sameh Trabelsi Nadia Jebabli Mohamed Lakhal Tarek Ben Othman Anis Kouz |
| author_sort | Hanene ELjebari |
| collection | DOAJ |
| description | Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym). The 10 models that have used CsA concentrations at a single time point did not have a good fit with AUC0–12 (R2<0.90). 𝐶2 and 𝐶4 were the time points that correlated best with AUC0–12 h, R2 were respectively 0.848, and 0.897. The LSS equation with the best predictive performance (bias, precision and number of samples) utilized three sampling concentrations was AUC0–12 h=0.607+1.569×𝐶0.5+2.098×𝐶2+3.603×𝐶4(R2=0.943). Optimal LSSs equations which limited to those utilizing three timed concentrations taken within 4 hours post-dose developed from ASCT recipient's patients yielded a low bias <5% ranged from 1.27% to 2.68% and good precision <15% ranged from 9.60% and 11.02%. We propose an LSS model with equation AUC0–12 h=0.82+2.766×𝐶2+3.409×𝐶4 for a practical reason. Bias and precision for this model are respectively 2.68% and 11.02%. |
| format | Article |
| id | doaj-art-eec116656d42427b9a1892c58d962b7a |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-eec116656d42427b9a1892c58d962b7a2025-02-03T01:25:59ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/342701342701Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral AdministrationHanene ELjebari0Nadia Ben Fradj1Issam Salouage2Emna Gaies3Sameh Trabelsi4Nadia Jebabli5Mohamed Lakhal6Tarek Ben Othman7Anis Kouz8Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaFaculté de Médecine de Tunis, 15 Rue Djebel Lakhdar La Rabta, Tunis 1007, TunisiaLaboratoire de Pharmacologie Clinique, Centre National de Pharmacovigilance, 9 Avenue Dr. Zouheïr Essafi, Tunis 1006, TunisiaMeasurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym). The 10 models that have used CsA concentrations at a single time point did not have a good fit with AUC0–12 (R2<0.90). 𝐶2 and 𝐶4 were the time points that correlated best with AUC0–12 h, R2 were respectively 0.848, and 0.897. The LSS equation with the best predictive performance (bias, precision and number of samples) utilized three sampling concentrations was AUC0–12 h=0.607+1.569×𝐶0.5+2.098×𝐶2+3.603×𝐶4(R2=0.943). Optimal LSSs equations which limited to those utilizing three timed concentrations taken within 4 hours post-dose developed from ASCT recipient's patients yielded a low bias <5% ranged from 1.27% to 2.68% and good precision <15% ranged from 9.60% and 11.02%. We propose an LSS model with equation AUC0–12 h=0.82+2.766×𝐶2+3.409×𝐶4 for a practical reason. Bias and precision for this model are respectively 2.68% and 11.02%.http://dx.doi.org/10.1155/2012/342701 |
| spellingShingle | Hanene ELjebari Nadia Ben Fradj Issam Salouage Emna Gaies Sameh Trabelsi Nadia Jebabli Mohamed Lakhal Tarek Ben Othman Anis Kouz Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration Journal of Transplantation |
| title | Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration |
| title_full | Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration |
| title_fullStr | Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration |
| title_full_unstemmed | Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration |
| title_short | Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration |
| title_sort | estimation of abbreviated cyclosporine a area under the concentration time curve in allogenic stem cell transplantation after oral administration |
| url | http://dx.doi.org/10.1155/2012/342701 |
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