Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis
Atherosclerosis, the leading cause of death worldwide, is a chronic inflammatory disease leading to the accumulation of lipid-rich plaques in the intima of large and medium-sized arteries. Accumulating evidence indicates the important regulatory role of the adaptive immune system in atherosclerosis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1502124/full |
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| author | Despina Giakomidi Despina Giakomidi Ayoola Ishola Meritxell Nus Meritxell Nus |
| author_facet | Despina Giakomidi Despina Giakomidi Ayoola Ishola Meritxell Nus Meritxell Nus |
| author_sort | Despina Giakomidi |
| collection | DOAJ |
| description | Atherosclerosis, the leading cause of death worldwide, is a chronic inflammatory disease leading to the accumulation of lipid-rich plaques in the intima of large and medium-sized arteries. Accumulating evidence indicates the important regulatory role of the adaptive immune system in atherosclerosis during all stages of the disease. The gut microbiome has also become a key regulator of atherosclerosis and immunomodulation. Whilst existing research extensively explores the impact of the microbiome on the innate immune system, only a handful of studies have explored the regulatory capacity of the microbiome on the adaptive immune system to modulate atherogenesis. Building on these concepts and the pitfalls on the gut microbiota and adaptive immune response interaction, this review explores potential strategies to therapeutically target the microbiome, including the use of prebiotics and vaccinations, which could influence the adaptive immune response and consequently plaque composition and development. |
| format | Article |
| id | doaj-art-eebf2ec0aca947dbb8acc53e8192eb4d |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-eebf2ec0aca947dbb8acc53e8192eb4d2025-01-31T06:40:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.15021241502124Targeting gut microbiota to regulate the adaptive immune response in atherosclerosisDespina Giakomidi0Despina Giakomidi1Ayoola Ishola2Meritxell Nus3Meritxell Nus4Cardiovascular Division, Department of Medicine, Heart and Lung Research Institute (HLRI), University of Cambridge, Cambridge, United KingdomBritish Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United KingdomCardiovascular Division, Department of Medicine, Heart and Lung Research Institute (HLRI), University of Cambridge, Cambridge, United KingdomCardiovascular Division, Department of Medicine, Heart and Lung Research Institute (HLRI), University of Cambridge, Cambridge, United KingdomBritish Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United KingdomAtherosclerosis, the leading cause of death worldwide, is a chronic inflammatory disease leading to the accumulation of lipid-rich plaques in the intima of large and medium-sized arteries. Accumulating evidence indicates the important regulatory role of the adaptive immune system in atherosclerosis during all stages of the disease. The gut microbiome has also become a key regulator of atherosclerosis and immunomodulation. Whilst existing research extensively explores the impact of the microbiome on the innate immune system, only a handful of studies have explored the regulatory capacity of the microbiome on the adaptive immune system to modulate atherogenesis. Building on these concepts and the pitfalls on the gut microbiota and adaptive immune response interaction, this review explores potential strategies to therapeutically target the microbiome, including the use of prebiotics and vaccinations, which could influence the adaptive immune response and consequently plaque composition and development.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1502124/fullatherosclerosisgut microbiotaT cellsB cellsmetabolites |
| spellingShingle | Despina Giakomidi Despina Giakomidi Ayoola Ishola Meritxell Nus Meritxell Nus Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis Frontiers in Cardiovascular Medicine atherosclerosis gut microbiota T cells B cells metabolites |
| title | Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis |
| title_full | Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis |
| title_fullStr | Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis |
| title_full_unstemmed | Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis |
| title_short | Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis |
| title_sort | targeting gut microbiota to regulate the adaptive immune response in atherosclerosis |
| topic | atherosclerosis gut microbiota T cells B cells metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1502124/full |
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