Specific modulation of CRISPR transcriptional activators through RNA-sensing guide RNAs in mammalian cells and zebrafish embryos

Specific modulation of CRISPR transcriptional activators through RNA-sensing guide RNAs in mammalian cells and zebrafish embryos

Cellular transcripts encode important information regarding cell identity and disease status. The activation of CRISPR in response to RNA biomarkers holds the potential for controlling CRISPR activity with spatiotemporal precision. This would enable the restriction of CRISPR activity to specific cel...

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Bibliographic Details
Main Authors: Oana Pelea, Sarah Mayes, Quentin RV Ferry, Tudor A Fulga, Tatjana Sauka-Spengler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
CRISPR
conditional activation
synthetic biology
RNA biomarkers
Online Access:https://elifesciences.org/articles/87722
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