Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants
Background and objectives: Cerebral tissue oxygen saturation (SctO2) and cerebral fractional tissue oxygen extraction (cFTOE) changes with GA in preterm infants. This study examines changes in frequency, duration, and severity of SctO2 desaturation and increased cFTOE with GA. Study design: The lowe...
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Elsevier
2025-01-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957224000809 |
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| author | M. Mohamed M. Frasketi H. Hoffman M. Elgendy S. Aly H. Aly |
| author_facet | M. Mohamed M. Frasketi H. Hoffman M. Elgendy S. Aly H. Aly |
| author_sort | M. Mohamed |
| collection | DOAJ |
| description | Background and objectives: Cerebral tissue oxygen saturation (SctO2) and cerebral fractional tissue oxygen extraction (cFTOE) changes with GA in preterm infants. This study examines changes in frequency, duration, and severity of SctO2 desaturation and increased cFTOE with GA. Study design: The lower limit of normal SctO2, the event threshold, was calculated using a tolerance interval method with 95% confidence interval (CI) and 90% probability. Cerebral desaturation events were defined as: 1) a drop below event threshold for at least 30 s (s), 2) preceded by a period above the event threshold for at least 30s, and 3) followed by a period above the threshold for at least 60s. Results: 86% of infants <28 wk experienced one or more SctO2 desaturation event compared to 57% in >28 wk, odds ratios (OR) 4.5 (CI:1.3–15.3, p = 0.016). The severity of SctO2 desaturation events decreases at a rate of 77.9 units per wk increase in GA (p < 0.001). 39.3% of infants <28 wk experienced one or more increased cFTOE events compared to 28.6% in >28 wk, OR 1.6 (CI:0.6–4.4, p = 0.35). The severity of increasing cFTOE events decreased by 69.7 units per wk increase in GA (p < 0.001). Conclusion: Cerebral tissue oxygen desaturation events decrease in frequency and severity with increasing GA. The severity of increased cFTOE episodes decrease with GA. |
| format | Article |
| id | doaj-art-eeadd0db357c456dabddefd2e8485d86 |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-eeadd0db357c456dabddefd2e8485d862025-01-25T04:11:06ZengElsevierPediatrics and Neonatology1875-95722025-01-016616065Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infantsM. Mohamed0M. Frasketi1H. Hoffman2M. Elgendy3S. Aly4H. Aly5Division of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA; Corresponding author. Cleveland Clinic Neonatology Cleveland Clinic Children's Hospital, 9500 Euclid Ave., Suite M3-136, Cleveland, OH, 44195, USA.Department of Biostatistics and Bioinformatics, The George Washington University, Milken Institute School of Public Health, Washington, DC, USADepartment of Biostatistics and Bioinformatics, The George Washington University, Milken Institute School of Public Health, Washington, DC, USADivision of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USADepartment of Cardiology, Boston Children's Hospital, Boston, MA, USADivision of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USABackground and objectives: Cerebral tissue oxygen saturation (SctO2) and cerebral fractional tissue oxygen extraction (cFTOE) changes with GA in preterm infants. This study examines changes in frequency, duration, and severity of SctO2 desaturation and increased cFTOE with GA. Study design: The lower limit of normal SctO2, the event threshold, was calculated using a tolerance interval method with 95% confidence interval (CI) and 90% probability. Cerebral desaturation events were defined as: 1) a drop below event threshold for at least 30 s (s), 2) preceded by a period above the event threshold for at least 30s, and 3) followed by a period above the threshold for at least 60s. Results: 86% of infants <28 wk experienced one or more SctO2 desaturation event compared to 57% in >28 wk, odds ratios (OR) 4.5 (CI:1.3–15.3, p = 0.016). The severity of SctO2 desaturation events decreases at a rate of 77.9 units per wk increase in GA (p < 0.001). 39.3% of infants <28 wk experienced one or more increased cFTOE events compared to 28.6% in >28 wk, OR 1.6 (CI:0.6–4.4, p = 0.35). The severity of increasing cFTOE events decreased by 69.7 units per wk increase in GA (p < 0.001). Conclusion: Cerebral tissue oxygen desaturation events decrease in frequency and severity with increasing GA. The severity of increased cFTOE episodes decrease with GA.http://www.sciencedirect.com/science/article/pii/S1875957224000809PretermVery low birth weightCerebral tissue oxygen saturationCerebral fractional tissue oxygen extractionNear-infrared spectroscopyTotal cerebral hemoglobin |
| spellingShingle | M. Mohamed M. Frasketi H. Hoffman M. Elgendy S. Aly H. Aly Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants Pediatrics and Neonatology Preterm Very low birth weight Cerebral tissue oxygen saturation Cerebral fractional tissue oxygen extraction Near-infrared spectroscopy Total cerebral hemoglobin |
| title | Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants |
| title_full | Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants |
| title_fullStr | Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants |
| title_full_unstemmed | Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants |
| title_short | Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants |
| title_sort | cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants |
| topic | Preterm Very low birth weight Cerebral tissue oxygen saturation Cerebral fractional tissue oxygen extraction Near-infrared spectroscopy Total cerebral hemoglobin |
| url | http://www.sciencedirect.com/science/article/pii/S1875957224000809 |
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