Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress
Liver damage caused by high doses of paracetamol is a global public health concern. Consequently, therapeutic strategies are being explored to prevent this damage. The bioactive compounds present in fruits have shown promise in protecting against disorders associated with paracetamol-induced liver d...
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Elsevier
2025-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000642 |
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| author | Clécia Dias Teixeira Priscila Oliveira Barbosa Wanderson Geraldo Lima Gustavo Silveira Breguez Miliane Martins de Andrade Fagundes Daniela Caldeira Costa Cintia Lopes de Brito Magalhães Joana Ferreira Amaral Melina Oliveira de Souza |
| author_facet | Clécia Dias Teixeira Priscila Oliveira Barbosa Wanderson Geraldo Lima Gustavo Silveira Breguez Miliane Martins de Andrade Fagundes Daniela Caldeira Costa Cintia Lopes de Brito Magalhães Joana Ferreira Amaral Melina Oliveira de Souza |
| author_sort | Clécia Dias Teixeira |
| collection | DOAJ |
| description | Liver damage caused by high doses of paracetamol is a global public health concern. Consequently, therapeutic strategies are being explored to prevent this damage. The bioactive compounds present in fruits have shown promise in protecting against disorders associated with paracetamol-induced liver damage. This study assessed the preventive effects of guarana powder on redox status in a rat model of acute hepatotoxicity induced by a toxic dose of paracetamol. Male Wistar rats were divided into four groups: control (C), guarana (G), paracetamol (P), and guarana + paracetamol (GP). Animals in groups G and GP received 300 mg/kg guarana powder daily for seven days. Hepatotoxicity was induced in the P and GP groups by a single dose of 3 g/kg paracetamol on the last day. Paracetamol effectively induced liver damage and oxidative stress in group P animals. Preventive treatment with guarana significantly mitigated this damage and prevented the serum elevation of ALT, AST, and ALP by 44 %, 29 %, and 24 %, respectively. It also prevented a 133 % increase in the necrotic liver area in GP animals compared to the P. Guarana treatment, which prevented reductions in glutathione levels, modulated antioxidant enzyme (SOD and CAT) expression and activity, and protein carbonylation, while enhancing the total antioxidant capacity. Our results suggest that preventive treatment with guarana can attenuate oxidative damage, modulate antioxidant defense gene expression, and protect against paracetamol-induced hepatotoxicity in rats, highlighting guarana powder as a potential therapeutic agent to prevent liver damage induced by high doses of paracetamol. |
| format | Article |
| id | doaj-art-eea72b371ab6442c8bb0e8070c1ebb0f |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-eea72b371ab6442c8bb0e8070c1ebb0f2025-02-06T05:11:49ZengElsevierToxicology Reports2214-75002025-06-0114101946Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stressClécia Dias Teixeira0Priscila Oliveira Barbosa1Wanderson Geraldo Lima2Gustavo Silveira Breguez3Miliane Martins de Andrade Fagundes4Daniela Caldeira Costa5Cintia Lopes de Brito Magalhães6Joana Ferreira Amaral7Melina Oliveira de Souza8Post-Graduate Program in Health and Nutrition (PPGSN), Nutrition School, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, BrazilDepartment of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, BrazilDepartment of Biological Sciences (DECBI), Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Minas Gerais, BrazilPost-Graduate Program in Health and Nutrition (PPGSN), Nutrition School, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, BrazilPost-Graduate Program in Health and Nutrition (PPGSN), Nutrition School, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, BrazilDepartment of Biological Sciences (DECBI), Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Minas Gerais, BrazilDepartment of Biological Sciences (DECBI), Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Minas Gerais, BrazilPost-Graduate Program in Health and Nutrition (PPGSN), Nutrition School, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, BrazilPost-Graduate Program in Health and Nutrition (PPGSN), Nutrition School, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil; Correspondence to: Laboratory of Nutritional Biochemistry and Molecular Biology, Department of Food, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais 35402-145, Brazil.Liver damage caused by high doses of paracetamol is a global public health concern. Consequently, therapeutic strategies are being explored to prevent this damage. The bioactive compounds present in fruits have shown promise in protecting against disorders associated with paracetamol-induced liver damage. This study assessed the preventive effects of guarana powder on redox status in a rat model of acute hepatotoxicity induced by a toxic dose of paracetamol. Male Wistar rats were divided into four groups: control (C), guarana (G), paracetamol (P), and guarana + paracetamol (GP). Animals in groups G and GP received 300 mg/kg guarana powder daily for seven days. Hepatotoxicity was induced in the P and GP groups by a single dose of 3 g/kg paracetamol on the last day. Paracetamol effectively induced liver damage and oxidative stress in group P animals. Preventive treatment with guarana significantly mitigated this damage and prevented the serum elevation of ALT, AST, and ALP by 44 %, 29 %, and 24 %, respectively. It also prevented a 133 % increase in the necrotic liver area in GP animals compared to the P. Guarana treatment, which prevented reductions in glutathione levels, modulated antioxidant enzyme (SOD and CAT) expression and activity, and protein carbonylation, while enhancing the total antioxidant capacity. Our results suggest that preventive treatment with guarana can attenuate oxidative damage, modulate antioxidant defense gene expression, and protect against paracetamol-induced hepatotoxicity in rats, highlighting guarana powder as a potential therapeutic agent to prevent liver damage induced by high doses of paracetamol.http://www.sciencedirect.com/science/article/pii/S2214750025000642GuaranaHepatotoxicityLiver injuryOxidative stressPaullinia cupanaParacetamol |
| spellingShingle | Clécia Dias Teixeira Priscila Oliveira Barbosa Wanderson Geraldo Lima Gustavo Silveira Breguez Miliane Martins de Andrade Fagundes Daniela Caldeira Costa Cintia Lopes de Brito Magalhães Joana Ferreira Amaral Melina Oliveira de Souza Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress Toxicology Reports Guarana Hepatotoxicity Liver injury Oxidative stress Paullinia cupana Paracetamol |
| title | Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress |
| title_full | Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress |
| title_fullStr | Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress |
| title_full_unstemmed | Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress |
| title_short | Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress |
| title_sort | preventive treatment with guarana powder paullinia cupana mitigates acute paracetamol induced hepatotoxicity by modulating oxidative stress |
| topic | Guarana Hepatotoxicity Liver injury Oxidative stress Paullinia cupana Paracetamol |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000642 |
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