Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain
Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix (ECM) in the brain. In adult mammals, CSPGs form the specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites of certain types of neurons. PNNs restrict synaptic plasticity and reg...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/256389 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558561619607552 |
|---|---|
| author | Noriko Horii-Hayashi Takayo Sasagawa Wataru Matsunaga Mayumi Nishi |
| author_facet | Noriko Horii-Hayashi Takayo Sasagawa Wataru Matsunaga Mayumi Nishi |
| author_sort | Noriko Horii-Hayashi |
| collection | DOAJ |
| description | Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix (ECM) in the brain. In adult mammals, CSPGs form the specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites of certain types of neurons. PNNs restrict synaptic plasticity and regulate the closure of critical periods. Although previous studies have examined the starting period of PNN formation, focusing on primary sensory cortices, there are no systematic studies at the whole brain level. Here, we examined the starting period of PNN formation in male mice ranging in age from postnatal day 3 to week 11, mainly focusing on several cortical areas, limbic structures, hypothalamus, and brain stem, using lectin histochemistry with Wisteria floribunda agglutinin (WFA). Results showed that early PNN formation was observed in several reticular formations of the brain stem related to the cranial nerves and primary somatosensory cortices. In the limbic system, PNN formation in the hippocampus started earlier than that of the amygdala. Furthermore, in the medial amygdaloid nucleus and some hypothalamic regions, WFA labeling did not show typical PNN-like forms. The present study suggests spatiotemporal differences at the beginning of PNN formation and a structural variety of CSPG-contained ECM in the brain. |
| format | Article |
| id | doaj-art-ee9c8b4cfbbf4d3389287fff984a8a2a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ee9c8b4cfbbf4d3389287fff984a8a2a2025-02-03T01:32:11ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/256389256389Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse BrainNoriko Horii-Hayashi0Takayo Sasagawa1Wataru Matsunaga2Mayumi Nishi3Department of Anatomy and Cell Biology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, JapanDepartment of Anatomy and Cell Biology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, JapanDepartment of Anatomy and Cell Biology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, JapanDepartment of Anatomy and Cell Biology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, JapanChondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix (ECM) in the brain. In adult mammals, CSPGs form the specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites of certain types of neurons. PNNs restrict synaptic plasticity and regulate the closure of critical periods. Although previous studies have examined the starting period of PNN formation, focusing on primary sensory cortices, there are no systematic studies at the whole brain level. Here, we examined the starting period of PNN formation in male mice ranging in age from postnatal day 3 to week 11, mainly focusing on several cortical areas, limbic structures, hypothalamus, and brain stem, using lectin histochemistry with Wisteria floribunda agglutinin (WFA). Results showed that early PNN formation was observed in several reticular formations of the brain stem related to the cranial nerves and primary somatosensory cortices. In the limbic system, PNN formation in the hippocampus started earlier than that of the amygdala. Furthermore, in the medial amygdaloid nucleus and some hypothalamic regions, WFA labeling did not show typical PNN-like forms. The present study suggests spatiotemporal differences at the beginning of PNN formation and a structural variety of CSPG-contained ECM in the brain.http://dx.doi.org/10.1155/2015/256389 |
| spellingShingle | Noriko Horii-Hayashi Takayo Sasagawa Wataru Matsunaga Mayumi Nishi Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain Neural Plasticity |
| title | Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain |
| title_full | Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain |
| title_fullStr | Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain |
| title_full_unstemmed | Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain |
| title_short | Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain |
| title_sort | development and structural variety of the chondroitin sulfate proteoglycans contained extracellular matrix in the mouse brain |
| url | http://dx.doi.org/10.1155/2015/256389 |
| work_keys_str_mv | AT norikohoriihayashi developmentandstructuralvarietyofthechondroitinsulfateproteoglycanscontainedextracellularmatrixinthemousebrain AT takayosasagawa developmentandstructuralvarietyofthechondroitinsulfateproteoglycanscontainedextracellularmatrixinthemousebrain AT watarumatsunaga developmentandstructuralvarietyofthechondroitinsulfateproteoglycanscontainedextracellularmatrixinthemousebrain AT mayuminishi developmentandstructuralvarietyofthechondroitinsulfateproteoglycanscontainedextracellularmatrixinthemousebrain |