Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice
Unfermented jujube pulp (UFJP), fermented jujube pulp (FJP) in high and low doses were fed to constipated ICR mice. Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. Results showed that high-dose FJP cou...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001003 |
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| author | Jing Li Xinyue Yu Xinxing Xu Peipei Tang Shuang Bi Xiaopu Ren Yong Shi Jihong Wu Fei Lao |
| author_facet | Jing Li Xinyue Yu Xinxing Xu Peipei Tang Shuang Bi Xiaopu Ren Yong Shi Jihong Wu Fei Lao |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Unfermented jujube pulp (UFJP), fermented jujube pulp (FJP) in high and low doses were fed to constipated ICR mice. Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. Results showed that high-dose FJP could protect intestinal mucosa tissue, shorten the first black feces defecating time by 17 % and increase the number and wet weights of black feces by 72 % and 71 %, respectively, within 6 h. High-dose FJP significantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice, compared with low-dose FJP and UFJP. High-dose FJP intervention regulated the microbiota profile, which afterwards restored microbiota, like Bacteroidetes, Bifidobacterium and Lactobacillus, to a less unhealthy state. This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health. |
| format | Article |
| id | doaj-art-ee967aaf55f247a09503c40731958060 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-ee967aaf55f247a09503c407319580602025-02-03T02:42:14ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112622862296Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR miceJing Li0Xinyue Yu1Xinxing Xu2Peipei Tang3Shuang Bi4Xiaopu Ren5Yong Shi6Jihong Wu7Fei Lao8National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaNational Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Beijing Daily Chemical Products Quality Supervision and Inspection Station, Beijing 101111, ChinaNational Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaDepartment of Food Science and Technology, The Ohio State University, Columbus 43210, USANational Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Engineering, Tarim University, Alar 843300, ChinaHaoxiangni Health Food Co., Ltd., Xinzheng 451100, ChinaNational Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Corresponding authors at: National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Corresponding authors at: National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.Unfermented jujube pulp (UFJP), fermented jujube pulp (FJP) in high and low doses were fed to constipated ICR mice. Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. Results showed that high-dose FJP could protect intestinal mucosa tissue, shorten the first black feces defecating time by 17 % and increase the number and wet weights of black feces by 72 % and 71 %, respectively, within 6 h. High-dose FJP significantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice, compared with low-dose FJP and UFJP. High-dose FJP intervention regulated the microbiota profile, which afterwards restored microbiota, like Bacteroidetes, Bifidobacterium and Lactobacillus, to a less unhealthy state. This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.http://www.sciencedirect.com/science/article/pii/S2213453023001003JujubeLactic acid bacteria fermentationShort-chain fatty acidProbioticsGut microbiota |
| spellingShingle | Jing Li Xinyue Yu Xinxing Xu Peipei Tang Shuang Bi Xiaopu Ren Yong Shi Jihong Wu Fei Lao Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice Food Science and Human Wellness Jujube Lactic acid bacteria fermentation Short-chain fatty acid Probiotics Gut microbiota |
| title | Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice |
| title_full | Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice |
| title_fullStr | Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice |
| title_full_unstemmed | Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice |
| title_short | Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice |
| title_sort | beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride induced constipation in male icr mice |
| topic | Jujube Lactic acid bacteria fermentation Short-chain fatty acid Probiotics Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001003 |
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