Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma
Abstract Background Primary pure mucinous adenocarcinoma of the lung (PMA) is a rare subtype. However, correlations between clinicopathological features and genetic phenotypes with survival have not been described comprehensively. Methods Pure mucinous adenocarcinoma patient information collected fr...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2726 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849224407587749888 |
|---|---|
| author | Zhencong Chen Ming Li Ke Ma Guoguo Shang Jiaqi Liang Jiacheng Yin Jizhuang Luo Cheng Zhan Yu Shi Qun Wang |
| author_facet | Zhencong Chen Ming Li Ke Ma Guoguo Shang Jiaqi Liang Jiacheng Yin Jizhuang Luo Cheng Zhan Yu Shi Qun Wang |
| author_sort | Zhencong Chen |
| collection | DOAJ |
| description | Abstract Background Primary pure mucinous adenocarcinoma of the lung (PMA) is a rare subtype. However, correlations between clinicopathological features and genetic phenotypes with survival have not been described comprehensively. Methods Pure mucinous adenocarcinoma patient information collected from the Surveillance, Epidemiology, and End Results (SEER) database, the Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (FDZSH), and the Cancer Genome Atlas (TCGA) were extracted, evaluated, and compared with other lung adenocarcinomas (LUAD) patient data. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to explore the functional importance of underlying molecular changes. Overall survival (OS) was evaluated with the Kaplan‐Meier method. Univariate and multivariate analysis through Cox proportional hazard regression identified risk factors that predicted OS, and the results were used to construct a nomogram to predict OS for PMA patients. Results Overall, 3622 patients, 41 patients, and 15 patients with PMA were identified from the SEER, FDZSH, and TCGA databases, respectively. There were 345 differentially expressed genes, 30 differentially mutated genes and 72 differentially methylated genes were identified between PMA and other LUAD samples. In the SEER database, PMA had a better prognosis compared to other LUAD. Compared with patients with other LUAD, patients with PMA exhibited unique clinicopathological features, including fewer grade III/IV tumors, less pleural invasion, more early‐stage cancer, and more lower lobe carcinomas. Multivariate analyses showed that age, race, T stage, N stage, surgery, and chemotherapy were independent risk factors. The nomogram had a calibration index of 0.724. Conclusions Our research identified unique clinicopathological characteristics and genetic phenotypes for PMA and other LUAD. The nomogram accurately predicted OS. |
| format | Article |
| id | doaj-art-ee943f2ee1ca420da0fd9dccdf1a154c |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-ee943f2ee1ca420da0fd9dccdf1a154c2025-08-25T10:14:04ZengWileyCancer Medicine2045-76342020-01-019251752910.1002/cam4.2726Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinomaZhencong Chen0Ming Li1Ke Ma2Guoguo Shang3Jiaqi Liang4Jiacheng Yin5Jizhuang Luo6Cheng Zhan7Yu Shi8Qun Wang9Department of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Pathology of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Thoracic of Zhongshan Hospital Fudan University Shanghai ChinaAbstract Background Primary pure mucinous adenocarcinoma of the lung (PMA) is a rare subtype. However, correlations between clinicopathological features and genetic phenotypes with survival have not been described comprehensively. Methods Pure mucinous adenocarcinoma patient information collected from the Surveillance, Epidemiology, and End Results (SEER) database, the Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (FDZSH), and the Cancer Genome Atlas (TCGA) were extracted, evaluated, and compared with other lung adenocarcinomas (LUAD) patient data. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to explore the functional importance of underlying molecular changes. Overall survival (OS) was evaluated with the Kaplan‐Meier method. Univariate and multivariate analysis through Cox proportional hazard regression identified risk factors that predicted OS, and the results were used to construct a nomogram to predict OS for PMA patients. Results Overall, 3622 patients, 41 patients, and 15 patients with PMA were identified from the SEER, FDZSH, and TCGA databases, respectively. There were 345 differentially expressed genes, 30 differentially mutated genes and 72 differentially methylated genes were identified between PMA and other LUAD samples. In the SEER database, PMA had a better prognosis compared to other LUAD. Compared with patients with other LUAD, patients with PMA exhibited unique clinicopathological features, including fewer grade III/IV tumors, less pleural invasion, more early‐stage cancer, and more lower lobe carcinomas. Multivariate analyses showed that age, race, T stage, N stage, surgery, and chemotherapy were independent risk factors. The nomogram had a calibration index of 0.724. Conclusions Our research identified unique clinicopathological characteristics and genetic phenotypes for PMA and other LUAD. The nomogram accurately predicted OS.https://doi.org/10.1002/cam4.2726clinicopathological featuresgenetic analysisnomogrampure mucinous adenocarcinomathe surveillance, epidemiology, and end results |
| spellingShingle | Zhencong Chen Ming Li Ke Ma Guoguo Shang Jiaqi Liang Jiacheng Yin Jizhuang Luo Cheng Zhan Yu Shi Qun Wang Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma Cancer Medicine clinicopathological features genetic analysis nomogram pure mucinous adenocarcinoma the surveillance, epidemiology, and end results |
| title | Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma |
| title_full | Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma |
| title_fullStr | Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma |
| title_full_unstemmed | Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma |
| title_short | Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma |
| title_sort | analysis of the clinicopathological characteristics genetic phenotypes and prognostic of pure mucinous adenocarcinoma |
| topic | clinicopathological features genetic analysis nomogram pure mucinous adenocarcinoma the surveillance, epidemiology, and end results |
| url | https://doi.org/10.1002/cam4.2726 |
| work_keys_str_mv | AT zhencongchen analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT mingli analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT kema analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT guoguoshang analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT jiaqiliang analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT jiachengyin analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT jizhuangluo analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT chengzhan analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT yushi analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma AT qunwang analysisoftheclinicopathologicalcharacteristicsgeneticphenotypesandprognosticofpuremucinousadenocarcinoma |