Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino
Abstract This study explored the genetic basis of growth traits in Middle Anatolian Merino lambs using multi-locus genome-wide association study (GWAS) analyses. Descriptive statistics indicated moderate heritability (h² = 0.363) for birth weight (BW) and (h² = 0.309) for weaning weight (WW), both s...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-024-04428-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850102884478222336 |
|---|---|
| author | Yalçın Yaman Şükrü DOĞAN Mesut KIRBAŞ A. Taner ÖNALDI Yavuz KAL |
| author_facet | Yalçın Yaman Şükrü DOĞAN Mesut KIRBAŞ A. Taner ÖNALDI Yavuz KAL |
| author_sort | Yalçın Yaman |
| collection | DOAJ |
| description | Abstract This study explored the genetic basis of growth traits in Middle Anatolian Merino lambs using multi-locus genome-wide association study (GWAS) analyses. Descriptive statistics indicated moderate heritability (h² = 0.363) for birth weight (BW) and (h² = 0.309) for weaning weight (WW), both statistically significant (p < 0.001). Strong genetic correlations were observed between WW and BW (rG = 0.922) and WW and Kleiber ratio (KR, rG = 0.896), implying that simultaneous improvements may be possible through targeted selection. Five multi-locus methods (mrMLM, FASTmrMLM, pLARmEB, FASTmrEMMA, and ISIS EM-BLASSO) were used to identify the polygenic basis of the traits. For BW and WW, 20 and 18 significant SNPs (LOD ≥ 5) were detected, respectively, with some SNPs co-detected by multiple methods. In contrast, only 10 significant SNPs were identified for KR, all exclusively by the ISIS EM-BLASSO approach. Pathway analyses within ± 100 Kb of associated SNPs revealed genes and pathways influencing these traits, which could be leveraged in future breeding programs for enhanced growth performance. The identified SNPs, particularly those associated with BW and WW traits, could facilitate genomic selection if validated in larger and more diverse populations. |
| format | Article |
| id | doaj-art-ee7a00a2a27f49bcac800b5bf8e7e4b9 |
| institution | DOAJ |
| issn | 1746-6148 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj-art-ee7a00a2a27f49bcac800b5bf8e7e4b92025-08-20T02:39:40ZengBMCBMC Veterinary Research1746-61482024-12-0120111410.1186/s12917-024-04428-7Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian MerinoYalçın Yaman0Şükrü DOĞAN1Mesut KIRBAŞ2A. Taner ÖNALDI3Yavuz KAL4Department of Genetics, Faculty of Veterinary Medicine, Siirt UniversityBahri Dagtas International Agricultural Research InstituteBahri Dagtas International Agricultural Research InstituteBahri Dagtas International Agricultural Research InstituteBahri Dagtas International Agricultural Research InstituteAbstract This study explored the genetic basis of growth traits in Middle Anatolian Merino lambs using multi-locus genome-wide association study (GWAS) analyses. Descriptive statistics indicated moderate heritability (h² = 0.363) for birth weight (BW) and (h² = 0.309) for weaning weight (WW), both statistically significant (p < 0.001). Strong genetic correlations were observed between WW and BW (rG = 0.922) and WW and Kleiber ratio (KR, rG = 0.896), implying that simultaneous improvements may be possible through targeted selection. Five multi-locus methods (mrMLM, FASTmrMLM, pLARmEB, FASTmrEMMA, and ISIS EM-BLASSO) were used to identify the polygenic basis of the traits. For BW and WW, 20 and 18 significant SNPs (LOD ≥ 5) were detected, respectively, with some SNPs co-detected by multiple methods. In contrast, only 10 significant SNPs were identified for KR, all exclusively by the ISIS EM-BLASSO approach. Pathway analyses within ± 100 Kb of associated SNPs revealed genes and pathways influencing these traits, which could be leveraged in future breeding programs for enhanced growth performance. The identified SNPs, particularly those associated with BW and WW traits, could facilitate genomic selection if validated in larger and more diverse populations.https://doi.org/10.1186/s12917-024-04428-7Multi-locus GWASGrowth traitsBirth weightWeaning weightKleiber ratioMiddle Anatolian Merino |
| spellingShingle | Yalçın Yaman Şükrü DOĞAN Mesut KIRBAŞ A. Taner ÖNALDI Yavuz KAL Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino BMC Veterinary Research Multi-locus GWAS Growth traits Birth weight Weaning weight Kleiber ratio Middle Anatolian Merino |
| title | Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino |
| title_full | Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino |
| title_fullStr | Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino |
| title_full_unstemmed | Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino |
| title_short | Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino |
| title_sort | investigation of growth traits in turkish merino lambs using multi locus gwas approaches middle anatolian merino |
| topic | Multi-locus GWAS Growth traits Birth weight Weaning weight Kleiber ratio Middle Anatolian Merino |
| url | https://doi.org/10.1186/s12917-024-04428-7 |
| work_keys_str_mv | AT yalcınyaman investigationofgrowthtraitsinturkishmerinolambsusingmultilocusgwasapproachesmiddleanatolianmerino AT sukrudogan investigationofgrowthtraitsinturkishmerinolambsusingmultilocusgwasapproachesmiddleanatolianmerino AT mesutkirbas investigationofgrowthtraitsinturkishmerinolambsusingmultilocusgwasapproachesmiddleanatolianmerino AT ataneronaldi investigationofgrowthtraitsinturkishmerinolambsusingmultilocusgwasapproachesmiddleanatolianmerino AT yavuzkal investigationofgrowthtraitsinturkishmerinolambsusingmultilocusgwasapproachesmiddleanatolianmerino |