Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i>
New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral <i>Anthothela g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/1/44 |
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| author | Stine S. H. Olsen Sam Afoullouss Ezequiel Cruz Rosa Ryan M. Young Mark Johnson A. Louise Allcock Bill. J. Baker |
| author_facet | Stine S. H. Olsen Sam Afoullouss Ezequiel Cruz Rosa Ryan M. Young Mark Johnson A. Louise Allcock Bill. J. Baker |
| author_sort | Stine S. H. Olsen |
| collection | DOAJ |
| description | New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral <i>Anthothela grandiflora,</i> we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F–Q. The metabolites were isolated using both bioassay- and <sup>1</sup>H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations of the anthoteibinenes. The metabolites were screened against the Respiratory Syncytial Virus (RSV), ESKAPE pathogens, five <i>Candida albicans</i> strains, and one strain of <i>C. auris</i>. |
| format | Article |
| id | doaj-art-ee7688f74aa047a898746837d85cd090 |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-ee7688f74aa047a898746837d85cd0902025-01-24T13:39:36ZengMDPI AGMarine Drugs1660-33972025-01-012314410.3390/md23010044Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i>Stine S. H. Olsen0Sam Afoullouss1Ezequiel Cruz Rosa2Ryan M. Young3Mark Johnson4A. Louise Allcock5Bill. J. Baker6Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USADepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USADepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USASchool of Natural Sciences and Ryan Institute, University of Galway, University Road, H91TK33 Galway, IrelandSchool of Natural Sciences and Ryan Institute, University of Galway, University Road, H91TK33 Galway, IrelandSchool of Natural Sciences and Ryan Institute, University of Galway, University Road, H91TK33 Galway, IrelandDepartment of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USANew technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral <i>Anthothela grandiflora,</i> we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F–Q. The metabolites were isolated using both bioassay- and <sup>1</sup>H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations of the anthoteibinenes. The metabolites were screened against the Respiratory Syncytial Virus (RSV), ESKAPE pathogens, five <i>Candida albicans</i> strains, and one strain of <i>C. auris</i>.https://www.mdpi.com/1660-3397/23/1/44deep-seacoralsesquiterpenecadinene<i>Anthothela</i><i>Candida</i> |
| spellingShingle | Stine S. H. Olsen Sam Afoullouss Ezequiel Cruz Rosa Ryan M. Young Mark Johnson A. Louise Allcock Bill. J. Baker Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i> Marine Drugs deep-sea coral sesquiterpene cadinene <i>Anthothela</i> <i>Candida</i> |
| title | Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i> |
| title_full | Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i> |
| title_fullStr | Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i> |
| title_full_unstemmed | Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i> |
| title_short | Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i> |
| title_sort | anthoteibinenes f q new sesquiterpenes from the irish deep sea coral i anthothela grandiflora i |
| topic | deep-sea coral sesquiterpene cadinene <i>Anthothela</i> <i>Candida</i> |
| url | https://www.mdpi.com/1660-3397/23/1/44 |
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