Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report
Abstract Amyloid myopathy often occurs in the context of systemic amyloidosis, as a rare manifestation of “light chain” (AL) amyloidosis, accounting for 1% of its incidence. A 58-year-old man with two years history of weakness and edema of lower extremity, elevated creatine kinase (CK), and inflamma...
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BMC
2024-11-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-024-03900-z |
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| author | Xingyu Han Mohammadreza Kosari Li Xu Yue Li Meng-ge Yang Huajie Gao Huizhen Ge Bitao Bu Suqiong Ji |
| author_facet | Xingyu Han Mohammadreza Kosari Li Xu Yue Li Meng-ge Yang Huajie Gao Huizhen Ge Bitao Bu Suqiong Ji |
| author_sort | Xingyu Han |
| collection | DOAJ |
| description | Abstract Amyloid myopathy often occurs in the context of systemic amyloidosis, as a rare manifestation of “light chain” (AL) amyloidosis, accounting for 1% of its incidence. A 58-year-old man with two years history of weakness and edema of lower extremity, elevated creatine kinase (CK), and inflammatory lesions from muscle biopsy which was misdiagnosed as inflammatory myopathy. After immunotherapy, the original symptoms worsened. We later confirmed the disease through MRI, Congo red staining and bone marrow puncture results. Our purpose is that to increase awareness of amyloid myopathy to minimize the risk of misdiagnosis and emphasize the importance of Congo red staining in diagnosing similar conditions. |
| format | Article |
| id | doaj-art-ee6de7f93c714f0b86572daf9eb4aab1 |
| institution | DOAJ |
| issn | 1471-2377 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-ee6de7f93c714f0b86572daf9eb4aab12025-08-20T02:49:16ZengBMCBMC Neurology1471-23772024-11-012411510.1186/s12883-024-03900-zAmyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case reportXingyu Han0Mohammadreza Kosari1Li Xu2Yue Li3Meng-ge Yang4Huajie Gao5Huizhen Ge6Bitao Bu7Suqiong Ji8Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyMBBS student, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Amyloid myopathy often occurs in the context of systemic amyloidosis, as a rare manifestation of “light chain” (AL) amyloidosis, accounting for 1% of its incidence. A 58-year-old man with two years history of weakness and edema of lower extremity, elevated creatine kinase (CK), and inflammatory lesions from muscle biopsy which was misdiagnosed as inflammatory myopathy. After immunotherapy, the original symptoms worsened. We later confirmed the disease through MRI, Congo red staining and bone marrow puncture results. Our purpose is that to increase awareness of amyloid myopathy to minimize the risk of misdiagnosis and emphasize the importance of Congo red staining in diagnosing similar conditions.https://doi.org/10.1186/s12883-024-03900-zAmyloid myopathyInflammatory myopathyCongo red stainingM proteinemia |
| spellingShingle | Xingyu Han Mohammadreza Kosari Li Xu Yue Li Meng-ge Yang Huajie Gao Huizhen Ge Bitao Bu Suqiong Ji Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report BMC Neurology Amyloid myopathy Inflammatory myopathy Congo red staining M proteinemia |
| title | Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report |
| title_full | Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report |
| title_fullStr | Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report |
| title_full_unstemmed | Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report |
| title_short | Amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using Congo red staining: a case report |
| title_sort | amyloid myopathy mimicked with idiopathic inflammatory myopathy diagnosed using congo red staining a case report |
| topic | Amyloid myopathy Inflammatory myopathy Congo red staining M proteinemia |
| url | https://doi.org/10.1186/s12883-024-03900-z |
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